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Table 1 Bacteriologic response does not predict clinical outcomes of pulmonary exacerbations

From: Reduction in Pseudomonas aeruginosa sputum density during a cystic fibrosis pulmonary exacerbation does not predict clinical response

Organism Morph Log drop Failure risk*
Actual values** OR (CI) P value
P. aeruginosa ALL 1 26% (18/68) vs 33% (17/51) 0.78 (0.46-1.38) 0.42
2 27% (15/55) vs 31% (20/64) 0.87 (0.5-1.5) 0.68
MUC 1 28% (21/74) vs 23% (6/26) 1.22 (0.56-2.70) 0.79
2 30% (17/56) vs 22% (10/44) 1.36 (0.68-2.62) 0.49
NON 1 30% (19/64) vs 35% (16/46) 0.85 (0.49-1.47) 0.68
2 33% (17/51) vs 30% (18/59) 1.1 (0.63-1.88) 0.84
S. aureus 2 46% (12/26) vs 0% (0/3) n/a 0.25
4 31% (5/16) vs 54% (7/13) 0.58 (0.28-1.58) 0.27
Oral Flora 1 22% (13/60) vs 34% (23/67) 0.63 (0.35-1.13) 0.12
2 23% (9/39) vs 31% (27/88) 0.75 (0.39-1.44) 0.52
  1. *Failure was defined as failing to achieve 90% of baseline percent predicted FEV1 at time of follow-up.
  2. **Risk of failure to achieve outcome in those PEx achieving the log drop in bacterial counts relative to those events where a drop was not observed.
  3. ALL = all P. aeruginosa morphotypes, MUC = mucoid, NON = non-mucoid isolates, OR = odds ration, CI = confidence intervals.