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Table 2 Cytokine production by splenocytes of immunized mice after stimulation by ROP18 protein at 8-weeks post immunization *

From: Protective efficacy of recombinant canine adenovirus type-2 expressing TgROP18 (CAV-2-ROP18) against acute and chronic Toxoplasma gondii infection in mice

Group (n = 3) Cytokine production (pg/mL) Proliferation (Stimulation Index)#
IFN-γ IL-2 IL-4 IL-10 ROP18 ConA
CAV-2-ROP18 (I) 914.26 ± 36.56a 431.07 ± 28.94a 197.29 ± 29.98a 44.37 ± 38.54a 4.87 ± 0.65a 2.93 ± 0.43a
CAV-2 (II) 44.28 ± 9.37b 47.23 ± 7.59b 52.65 ± 9.24b 38.49 ± 5.48a 0.23 ± 0.06b 3.07 ± 0.19a
PBS (III) 46.13 ± 10.27b 52.60 ± 11.97b 54.87 ± 9.45b 41.36 ± 5.23a 0.26 ± 0.10b 2.81 ± 0.32a
Blank Control (IV) 42.98 ± 6.76b 51.45 ± 3.88b 53.38 ± 5.97b 40.63 ± 6.74a 0.27 ± 0.07b 2.84 ± 0.26a
  1. *Data are reported as mean ± SD.
  2. #Splenocytes from mice were collected 8-weeks after the immunization.
  3. Values for IL-10 and IFN-γ are for 72 h, values for IL-2 and IL-4 are for 24 h.
  4. Within each column, groups with different superscripts are different (P < 0.05).