You are viewing the site in preview mode

Skip to main content

Advertisement

Table 2 HLA alleles with statistically significant differences in BB, BT, and BL patients and healthy controls

From: Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil

BB HLA allele Patients (N = 88) Controls (N = 478) p pc OR IC
   N % n %     
  B*49 0 0.00 29 6.07 0.014 0.448 0.09 0.005–1.42
  B*58 10 11.36 24 5.03 0.028 0.896 2.42 1.11–5.27
  C*05 5 5.68 67 14.02 0.035 0.49 0.37 0.14–0.94
  C*12 19 21.59 64 13.39 0.050 0.70 1.78 1.00–3.15
BT   Patients (N = 70) Controls (N = 478)     
  A*33 8 11.43 25 5.23 0.056 1.12 2.34 1.01–5.41
  B*40 2 2.86 50 10.46 0.047 1.50 0.25 0.06–1.06
  B*49 0 0.00 29 6.07 0.039 1.24 0.11 0.006–1.79
  B*53 6 8.57 14 2.93 0.031 0.992 3.11 1.15–8.37
  C*05 3 4.28 67 14.02 0.020 0.28 0.27 0.08–0.89
  C*16 9 12.86 26 5.44 0.031 0.434 2.56 1.15–5.73
  DRB1*03 20 28.57 85 17.78 0.049 0.637 1.85 1.05–3.27
BL   Patients (N = 44) Controls (N = 478)     
  B*53 4 9.09 14 2.93 0.056 1.792 3.31 1.04–10.54
  DRB1*07 5 11.36 128 26.77 0.028 0.364 0.35 0.13–0.91
  DQB1*02 8 18.18 189 39.53 0.005 0.025 0.34 0.15–0.75
  1. N: number of individuals, n: number of alleles (2n), %: allele frequency, p: Fisher’s exact test (p ≤ 0.05), pc: corrected p value, OR: odds ratio, CI: confidence interval, boldface: significant association after Bonferroni´s correction.