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Table 2 Participant characteristics and outcomes by M. tuberculosis bacteremia status, ACTG A5221 STRIDE study

From: Predictors and outcomes of Mycobacterium tuberculosis bacteremia among patients with HIV and tuberculosis co-infection enrolled in the ACTG A5221 STRIDE study

  M. tuberculosis bacteremia  
  Total Yes No p-value a
  n/ n (%) n/ n (%) n/ n (%)  
Participant characteristics           
Male sex 61/ 90 (67.8) 9/ 18 (50.0) 52/ 72 (72.2) 0.092
Enrollment at an African site 38/ 90 (42.2) 9/ 18 (50.0) 29/ 72 (40.3) 0.595
Age (years)b 37.0 (31.0, 45.0) 33.0 (29.0, 37.0) 38.0 (31.0, 45.4) 0.056
CD4 count (cells/mm3)b 81.0 (33.0, 131.0) 35.0 (16.0, 62.0) 91.0 (39.0, 146.5) <0.001
HIV RNA (log10 copies/mL)b 5.4 (5.0, 5.8) 5.7 (5.4, 5.9) 5.3 (4.8, 5.8) 0.019
Presence of an AIDS-defining illness 8/ 90 (8.9) 2/ 18 (11.1) 6/ 72 (8.3) 0.658
Body mass index (BMI, kg/m2)b 18.9 (17.2, 20.9) 17.3 (15.6, 20.6) 19.2 (17.9, 21.1) 0.026
Hemoglobin ≤8.5 g/dL 17/ 90 (18.9) 8/ 18 (44.4) 9/ 72 (12.5) 0.005
Self-reported cough 4/ 90 (4.4) 1/ 18 (5.6) 3/ 72 (4.2) 1.000
Self-reported weight loss 12/ 90 (13.3) 4/ 18 (22.2) 8/ 72 (11.1) 0.248
Self-reported fever 2/ 90 (2.2) 0/ 18 (0.0) 2/ 72 (2.8) 1.000
Confirmed tuberculosis at entry 50/ 90 (55.6) 17/ 18 (94.4) 33/ 72 (45.8) <0.001
Early ART initiation 42/ 90 (46.7) 9/ 18 (50.0) 33/ 72 (45.8) 0.796
Outcome           
Immune reconstitution inflammatory syndrome 11/ 90 (12.2) 2/ 18 (11.1) 9/ 72 (12.5) 1.000
HIV-1 RNA level <400 copies/mL at week 48 69/ 82 (84.1) 16/ 16 (100.0) 53/ 66 (80.3) 0.062
CD4 count increase ≥100 cells/mm3 at week 48 63/ 85 (74.1) 15/ 16 (93.8) 48/ 69 (69.6) 0.059
Interruption or discontinuation of tuberculosis medications 22/ 90 (24.4) 7/ 18 (38.9) 15/ 72 (20.8) 0.131
Interruption or discontinuation of ARTc 7/ 85 (8.2) 3/ 16 (18.8) 4/ 69 (5.8) 0.120
Sputum smear conversion baseline to week 8d 12/ 35 (34.3) 7/ 10 (70.0) 5/ 25 (20.0) 0.008
Sputum culture conversion baseline to week 8d 17/ 23 (73.9) 3/ 4 (75.0) 14/ 19 (73.7) 1.000
  1. aFisher’s Exact test, except for age, CD4 count, HIV RNA, BMI, sputum smear and culture conversion which were exact Wilcoxon test.
  2. bMedian (IQR) values are presented for age, CD4 count, HIV RNA, and BMI.
  3. cART: antiretroviral therapy.
  4. dFrom positive to negative.