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Table 3 Significantly correlated pairs of mutations

From: Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs

Mutation 1 Frequency Mutation 2 Frequency Covariation Frequency Phib P-value c
  N (%)a   N (%)a N (%)   
RT       
M41L 4 (1.9) L210W 6 (2.8) 3 (1.4) 0.6 0.02
L210W 6 (2.8) T215D 5 (2.3) 5 (2.3) 0.9 <0.001
L210W 6 (2.8) K103N 7 (3.3) 3 (1.4) 0.4 0.04
T215D 6 (2.8) V60I 34 (16.0) 5 (2.3) 0.3 0.02
  1. aThe frequency was determined in 213 HIV-1 B isolates from drug-naïve patients.
  2. bPositive correlations and negative correlations with phi >0.15 and phi <-0.07 are shown, respectively.
  3. cAll P values for covariation were significant at a false discovery rate of 0.05 following correction for multiple-hypothesis testing (Benjamini-Hochberg method).