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Table 4 Benefit Variables used in model with 'baseline', 'low' and 'high' values, and sources

From: Perinatal HIV transmission and the cost-effectiveness of screening at 14 weeks gestation, at the onset of labour and the rapid testing of infants

Variable Baseline (Low, High) Source
Percentage of pregnant women unscreened through existing practice 70% (50%, 90%) [17, 18]
Annual population pregnant women 1522 (1142, 1903) [20]
Percentage pregnant women that accept screening – 14 wks gestation 95% (63%, 100%) [17, 4648]
Percentage pregnant women that accept screening – onset of labour 85% (67%, 100%) [17, 49, 50]
Percentage pregnant women that accept screening – infant at birth 90% (67%, 100%) [17, 50]
Percentage pregnant women that accept ART – 14 wks gestation 75% (50%, 95%) [18, 51]
Percentage pregnant women that accept ART – onset of labour 75% (50%, 100%) [18]
Percentage of pregnant women that accept ART – infant after birth 75% (50%, 100%) [18]
Prevalence of undiagnosed HIV in women of childbearing age 4.9% (3.6%, 6.1%) [18, 52]
Additional percentage of screened women who hadn't seroconverted at time of first test or contracted HIV since first test 2% (0%, 6%) [17, 25, 50]
% of women who seek antenatal care prior by 14 weeks gestation 63.4% (47.6%, 79.4%) [17, 20]
% of women who seek antenatal care after 14 weeks and present to hospital in sufficient time prior to delivery 25.2% (19.5%, 32.5%) [17, 20]
Termination of pregnancy in diagnosed HIV+ mothers 1% (0%, 5%) [17, 53]
TR without treatment – no breastfeeding 28% (16%, 33%) [24]
TR with treatment from 14 wks gestation- no breastfeeding 2% (1%, 7.3%) [4, 5, 54]
TR with treatment from onset of labour – no breastfeeding 10% (5%, 15%) [4, 14, 15]
TR with treatment within 24 hours birth – no breastfeeding 13.1% (8.9%, 17.3%) [15, 16]
Life Expectancy HIV- infant 77.74 (58, 97) [20]
Time to Diagnosis of HIV+ infant without screening (months) 5.2 (3.9. 13.0) [55, 56]
HIV+ infant – % FP 25% (5%, 40%) [2224]
HIV + infant – Time in HIV phase NP (screened) (yrs) 8.5 (5.7, 13.5) [57]
HIV+ infant – Time in HIV phase NP (unscreened) (yrs) 6.2 (4.7, 8.5) [57]
HIV+ infant – Time in HIV phase FP (screened) (yrs) 0.75 (0.25, 1.25) [18, 57]
HIV+ infant – Time in HIV phase FP (unscreened) (yrs) 0.5 (0.0, 1.0) [18, 57]
HIV+ infant – Time in AIDS phase NP (screened) (yrs) 4.6 (1.7, 10.3) [18, 57]
HIV+ infant – Time in AIDS phase NP (unscreened) (yrs) 3.9 (1.5, 9.7) [57]
HIV+ infant – Time in AIDS phase FP (screened) (yrs) 0.75 (0.25, 1.25) [2224]
HIV+ infant – Time in AIDS phase FP (unscreened) (yrs) 0.5 (0.0, 1.0) [18, 2224]
Life expectancy HIV+ mother from diagnosis (normal diagnosis path) (years) 12.0 (9.8, 18.2) [58]
Life expectancy HIV+ mother from diagnosis (early diagnosis due to screening) (years) 12.70 (9.9, 15.0) [58]
Time to diagnosis of HIV+ mother without screening (months) 20.4 (15.0, 25.5) [58]
  1. TR = Transmission Rate
  2. FP = Fast Progressor
  3. NP = Normal Progressor