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Table 3 Reasons for inadequacy of empirical and adjusted antibiotic therapies

From: Empirical use of antibiotics and adjustment of empirical antibiotic therapies in a university hospital: a prospective observational study

Reason for inadequacy a Number of patients %
Empirical antibiotic therapies 539  
Inadequate empirical therapy 121 100%
Spectrum too broad 29 24.0%
Inadequate duration 28 23.1%
Insufficient dosage 27 22.3%
Spectrum too narrow 22 18.2%
Wrong spectrum/inadequate use b 21 17.4%
Excessive dosage 3 2.5%
Adjusted antibiotic therapies 168  
Inadequate adjusted therapy 46 100%
Spectrum too broad 24 52.2%
Wrong spectrum/inadequate use c 12 26.1%
Insufficient dosage 7 15.2%
Inadequate duration 2 4.4%
Excessive dosage 1 2.2%
Spectrum too narrow 1 2.2%
  1. a More than one reason may apply for each patient.
  2. b If antibiotic given covered completely different spectrum than expected bacteria would require or no antibiotic therapy was warranted.
  3. c If bacteriological results had shown that identified bacteria were resistant to antibiotics used, or antibiotic covered completely different spectrum than expected bacteria would require or no antibiotic therapy was warranted.