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Table 5 Mutational frequencies of levofloxacin, vancomycin, teicoplanin, amikacin, ceftazidime, cefepime, imipenem and piperacillin/tazobactam alone and in triple combinations

From: In vitro evaluation of antibiotics' combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureussevere respiratory infections

Strain LVX VA TEC AMK CAZ FEP IPM TZP Triple combinations*
7095 <10-9 <10-9 <10-9 4.52 × 10-7 n.d. n.d. n.d. <10-9 <10-9
7096 <10-9 <10-9 <10-9 1.6 × 10-7 n.d. n.d. 1.03 × 10-6 n.d. <10-9
8957 4.9 × 10-5 <10-9 <10-9 <10-9 n.d. n.d. n.d. n.d. <10-9
7176 2.4 × 10-6 <10-9 <10-9 3.65 × 10-8 n.d. n.d. 8.52 × 10-5 n.d. <10-9
7171 <10-9 <10-9 <10-9 7.57 × 10-7 n.d. n.d. n.d. n.d. <10-9
2106 n.d. <10-9 <10-9 <10-9 n.d. n.d. 2.3 × 10-5 n.d. <10-9
7117 n.d. <10-9 <10-9 7.24 × 10-7 n.d. n.d. n.d. n.d. <10-9
7169 n.d. <10-9 <10-9 <10-9 n.d. n.d. n.d. n.d. <10-9
6491 n.d. <10-9 <10-9 6 × 10-8 n.d. n.d. n.d. n.d. <10-9
  1. LVX: levofloxacin; VA: vancomycin; TEC: teicoplanin; AMK: amikacin; CAZ: ceftazidime; FEP: cefepime; IPM: imipenem; TZP: piperacillin/tazobactam.
  2. n.d.: not determined (strain resistant to the antibiotic)
  3. *Triple combinations: LVX+VA+AMK; LVX+VA+CAZ; LVX+VA+FEP; LVX+VA+IPM; LVX+VA+TZP; LVX+VA+AMK; LVX+TEC+CAZ; LVX+TEC+FEP; LVX+TEC+IPM; LVX+TEC+TZP.