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Table 4 Mutational frequencies of levofloxacin, vancomycin, teicoplanin and cefotaxime alone and in double combination

From: In vitro evaluation of antibiotics' combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureussevere respiratory infections

Strain Single antibiotics Double combinations*
  LVX VA TEC CTX  
7095 <10-9 <10-9 <10-9 n.d. <10-9
7096 <10-9 <10-9 <10-9 n.d. <10-9
8957 1.65 × 10-5 <10-9 <10-9 n.d. <10-9
7176 1.81 × 10-6 <10-9 <10-9 n.d. <10-9
7171 <10-9 <10-9 <10-9 n.d. <10-9
2106 <10-9 <10-9 <10-9 n.d. <10-9
6556 2.86 × 10-7 <10-9 <10-9 5.47 × 10-5 <10-9
7169 n.d. <10-9 <10-9 1.22 × 10-5 <10-9
7955 n.d. <10-9 <10-9 n.d. <10-9
8363 n.d. <10-9 <10-9 n.d. <10-9
  1. LVX: levofloxacin; VA: vancomycin; TEC: teicoplanin; CTX: cefotaxime.
  2. n.d.: not determined (strain resistant to the antibiotic)
  3. *Double combinations: LVX + VA; LVX + TP; CTX + VA; CTX + TP