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Table 2 Association between genotype and disease severity

From: Common TNF-α, IL-1β, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis

Genotype Sepsis (%) Severe sepsis (%) Septic shock (%) All (%) P value
TNF-α (G-308A)      
GG 134 (60) 35 (58) 13 (65) 182 (60)  
GA 80 (36) 20 (33) 6 (30) 106 (35)  
AA 10 (4) 5 (9) 1 (5) 16 (5) 0.92
Il-1β (C3953T)      
CC 135 (57) 32 (53) 11 (52) 178 (56)  
CT 83 (35) 24 (40) 10 (48) 117 (37)  
TT 18 (8) 4 (7) 0 22 (7) 0.5
PAI-1 (4G/5G)      
4G-4G 67 (28) 16 (27) 7 (33) 90 (28)  
4G-5G 134 (58) 37 (62) 12 (57) 183 (58)  
5G-5G 35 (14) 7 (11) 2 (10) 44 (14) 0.89
uPA (C422T)      
CC 135 (58) 41 (67) 11 (52) 187 (60)  
CT 87 (38) 19 (31) 8 (38) 114 (36)  
TT 9 (4) 1 (2) 2 (10) 12 (4) 0.30
TLR4 (A 896G)      
AA 204 (91) 52 (91) 18 (86) 274 (91)  
AG 19 (9) 5 (9) 3 (14) 27 (9)  
GG 0 0 0 0 0.52
CD14 (C-159T)      
CC 72 (31) 13 (22) 7 (33) 92 (29)  
CT 117 (50) 30 (51) 9 (43) 156 (50)  
TT 45 (19) 16 (27) 5 (24) 66 (21) 0.57
  1. TNF-α: tumor necrosis factor alpha; Il-1β: interleukin-1 beta; PAI-1: plasminogen activator inhibitor 1; uPA: urokinase-type plasminogen activator; TLR4: toll-like receptor 4; CD14: cluster of differentiation 14; A: adenine; T: thymidine; C: cytosine; G: guanine