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Table 1 Particulars of 27 blood culture-positive candidemia patients and results on detection of species-specific Candida DNA, (1,3)-beta-D-glucan, mannan and anti-mannan antibodies by diagnostic kit cut-off value

From: Comparative evaluation of (1, 3)-β-D-glucan, mannan and anti-mannan antibodies, and Candidaspecies-specific snPCR in patients with candidemia

Case no Age/sex Underlying condition Blood culture Semi-nested PCR with serum BDG (pg/ml) Mannan (ng/ml) Anti-mannan Abs (AU/ml)
1 88/F Septicemia, Chest infection C. albicans C. albicans, C. parapsilosis 35 0.32 9.8
1b* 88/F Septicemia, Chest infection C albicans C. albicans 53 0.32 11.2
2 49/F Chronic renal failure C. albicans C. albicans 40 0.26 0.8
3 79/M Large bowel obstruction C. albicans C. albicans 172 0.8 13.2
4 17/M Aseptic meningitis C. albicans C. albicans 20 0.28 2.4
5 34/M Gut surgery C. albicans C. albicans 130 0.66 6.8
6 50/M Pancytopenia C. albicans C. albicans, C. parapsilosis 30 0.52 0.8
7 56/M Appendicular mass C. albicans C. albicans 44 1.3 10.6
7b* 56/M Appendicular mass C albicans C. parapsilosis 69 0.38 9.6
8 35/M - C. albicans C. tropicalis 131 0.86 20.6
9 42/M - C. albicans C. albicans 43 0.5 3
10 26/F Small bowel obstruction, pancreatitis C. albicans C. albicans, C. parapsilosis 32 0.48 8
10b* 26/F Small bowel obstruction, pancreatitis C. albicans -ve 21 0.22 34
11 22/F - C. albicans -ve 48 0.36 24.4
12 78/F Laparotomy C. albicans -ve 28 0.3 20.8
12b* 78/F Laparotomy C. albicans -ve 22 0.34 27.8
13 71/F Laparotomy C. albicans C. albicans, C. tropicalis 127 1.44 2
14 9mo/F Pneumonia C. albicans C. parapsilosis 112 3.19 1
15 68/M Bladder cancer C. albicans C. parapsilosis 157 0.36 35
16 58/M Renal failure C. albicans C. albicans 254 1.54 7
17 77/M Chest trauma C. albicans C. albicans 97 0.64 1.6
18 48/M Bronchopneumonia C. albicans C. albicans 321 0.24 23.8
19 20/F Meningitis C. parapsilosis C. albicans 32 0.34 11.2
20 80/M Urinary tract infection C. parapsilosis C. parapsilosis 120 0.3 19.4
21 54/F Diabetes mellitus, LVF C. parapsilosis C. parapsilosis 65 0.22 1.4
22 04/M Head injury C. parapsilosis C. albicans 20 0.28 2.2
23 6mo/F Pneumonia C. parapsilosis C. parapsilosis 101 0.62 2.2
24 80/M Chest infection C. tropicalis C. tropicalis, C. albicans, C. parapsilosis 47 0.48 7
25 41/M Polyarteritis nodusa C. tropicalis C. tropicalis 115 2.8 1.4
25b* 41/M Polyarteritis nodusa C. tropicalis C. tropicalis 108 0.4 19.4
26 74/M Jaundice, fever C. tropicalis C. parapsilosis 205 1.88 12.4
27 28/M Thrombocytopenia C. kruseii C. albicans 132 0.2 13.4
  1. Age is expressed in years unless indicated. mo: months, LVF: left ventricular failure, BAL: broncho-alveolar lavage, M: male, F: female, * repeated specimen of the respective patient, – : not grown/information not available
  2. Interpretation of results:
  3. Mannan Ag: positive = > 0.5 ng/ml, intermediate = 0.25–0.5 ng/ml, negative = < 0.25 ng/ml; Anti-mannan antibodies: positive = > 10 AU/ml, intermediate = 5–10 AU/ml, negative = < 5 AU/ml; BDG: positive = = 80 pg/ml, equivocal = > 60 < 80 pg/ml, negative = < 60 pg/ml; positive results are shown in bold letters