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Table 1 Median (range) of histopathologic and immunohistologic rankings of features among patients with HME, RMSF, or controls. High ranks correspond to a greater degree for each histologic or immunohistologic feature.

From: Lymph node hemophagocytosis in rickettsial diseases: a pathogenetic role for CD8 T lymphocytes in human monocytic ehrlichiosis (HME)?

Histologic Feature n = 19 HME n = 6 RMSF n = 5 P HME vs. RMSF Controls n = 8 P HME vs. controls P RMSF vs. controls
Cellularity 11.5 (1–17) 4 (2–8) .063 13.5 (7–19) .245 .002
Phagocytic activity 15 (3.5–19) 13 (3.5–17) .268 3.5 (3.5–12) .015 .033
Necrosis 10.75 (2.5–18) 10.5 (2.5–13) .396 10.5 (3–19) .377 .584
Congestion/edema 11.5 (2–19) 8 (2–18) .396 11.5 (2–17) .638 .262
Bacterial load* 1.3 3.0 .003 1.5 .447 .025
Immunohistologic feature HME [n] Controls [n]*** P HME vs. controls
CD68 [n = 9] 7 [5] (1–10) 3.5 [4] (2–8) .143
CD4 [n = 8**] 5 [4**] (3–9) 6 [4] (2–8) 1.000
CD8 [n = 9] 8 [5] (6–10) 2.5 [4] (1–5) .008
CD20 [n = 7**] 6 [3**] (3–8) 3.5 [4] (1–7) .288
  1. * means and Student's t-tests for semiquantitative measurement of bacterial load
  2. ** immunostaining for CD4 and CD20 was unsatisfactory for 1 and 2 HME patients, respectively.
  3. *** includes 1 case each of murine typhus, cat scratch disease, bronchopneumonia, and subarachnoid hemorrhage