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Table 2 Description of studies and the associated cure rates

From: Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review

Author Publication year Sample size1 S. aureus positive culture (%) Parenteral (IV) antimicrobial Days of IV treatment Mean (range) Oral antimicrobial Days of oral treatment Mean (range) Cure rate % (CI)
Long Course
Kolyvas2 1980 5 50.03 Cephradine +/- Ampicillin 28 (28–28) Cephradine or Cloxacillin 18 (14–35) 100 (67, 100)
Tetzlaff 1978 18 100.0 Methicillin or Cefazolin 8 (7–13) Cephalexin or Penicillin V 20 (13–42) 94 (77, 100)
Bryson 1979 18 100.0 Oxacillin or Methicillin 7 (5–14) Dicloxacillin N/A (28–56) 100 (89, 100)
Rodriguez 1977 21 90.5 Clindamycin4 25 (21–28) Clindamycin 42 (42–42) 100 (91, 100)
Prober 1979 22 100.0 Nafcillin or Methicillin 145 (4–28) Dicloxacillin 283 (N/A) 100 (91, 100)
Short Course
Kolyvas2 1980 5 50.03   3 (N/A) Cephradine or Cloxacillin 423 (39–60)3 100 (67, 100)
Refass6 1989 6 98.9 Cloxacillin N/A (5–6) Flucloxacillin N/A (7–200)3 100 (72, 100)
Freij 1987 8 100.0 Imipenem + Cilastatin 5.5 (4–9) Cefaclor or Dicloxacillin or Cephalexin or Bacampicillin or Penicillin V 15 (13–19) 88 (55, 100)
Feigin7 1975 11 72.7 Clindamycin 6 (3–13) Clindamycin 425 (N/A) 91 (65, 100)
Geddes8 1977 18 65.03 Clindamycin 63 (N/A) Clindamycin 903 (N/A) 94 (77, 100)
Cole9 1982 48 94.5 Cloxacillin or Cephalothin 3 (2–5) Cloxacillin or Cephalexin 39 (37–40) 92 (81, 97)
Peltola 1997 50 100.0 Cephradine or Cephalothin or Clindamycin 4 (4–6) Cefadroxil or Clindamycin 19 (17–19) 100 (96, 100)
  1. 1 Includes cases that were due to Staphylococcus aureus and those who were culture negative 2 Included only the cases that had osteomyelitis alone or had contiguous arthritis and osteomyelitis. 3 Estimated value. 4 Clindamycin is the only macrolide studied – all other antimicrobials mentioned are beta-lactams. 5 Median reported. 6 Only the 6 patients who clearly met the diagnostic criteria were included. 7 Data abstracted from the 11 cases of osteomyelitis (8 of whom had S. aureus). 8 Only data for the 18 children with acute osteomyelitis from the study were included. Some of these may only have received oral medication. 9 Data from the 48 patients for whom there was follow-up of greater than 6 months.