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  • Poster presentation
  • Open Access

Anti NMDA-receptor encephalitis: a severe case (34 year-old male) with psychotic disorders

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BMC Infectious Diseases201414 (Suppl 7) :P89

  • Published:


  • Encephalitis
  • Psychotic Disorder
  • Paraneoplastic Syndrome
  • Altered State
  • Advanced Life Support


Acute encephalitis associated with antibodies to the N-methyl-D-aspartate subtype of glutamate receptor is a recently described condition, the majority of cases presenting as a paraneoplastic syndrome in young females.

Case report

We report the case of a 34 years-old male with anti-NMDA receptor encephalitis who exhibited the classical pattern. The patient described psychiatric symptoms, seizures, movement disorders, altered state of consciousness and autonomic dysfunction, over the course of 40-50 days. After a 20-day hospitalization in a psychiatric ward, the case was redirected to our infectious disease – intensive care facility, where he required advanced life support. The interdisciplinary team of infectious diseases, intensive care and neurology specialists raised the diagnosis suspicion of encephalitis. The patient received empirical corticotherapy and therapeutic plasma exchange, with significant clinical improvement in the second week of treatment, coinciding with the diagnostic confirmation by positive results for anti-NMDA receptor antibodies in both serum and cerebrospinal fluid.

The patient continued his recovery in a specialized neurology department. Infectious disease specialists are often confronted with encephalitis of unknown etiology.


Collaboration with neurologists and psychiatrists with knowledge of this disorder is very important for an early diagnosis and treatment, as full recovery is a possible outcome for these patients with the correct case management.


Authors’ Affiliations

National Institute for Infectious Diseases "Prof. Dr. Matei Balş", Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania


© Roşculeț et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.