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  • Poster presentation
  • Open Access

Human immunodeficiency virus infection and cardiovascular risk

  • 1Email author,
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  • 1,
  • 1,
  • 2 and
  • 3
BMC Infectious Diseases201414 (Suppl 7) :P83

  • Published:


  • Human Immunodeficiency Virus
  • Total Cholesterol
  • Cardiovascular Risk
  • Significant Statistical Difference
  • Framingham Score


Cardiovascular diseases are the second leading non-AIDS dependent cause of mortality for human immunodeficiency virus-infected (HIV) patients. Thus, the evaluation of cardiovascular risk factors (CVRF) and the identification of persons at risk are necessary for the implementation of prevention methods.


A retrospective cross-sectional study was performed on a group of 50 HIV patients at the I Clinic of Infectious Diseases Tg Mureş (33 male, average age: 27.1±7; average duration of antiretroviral treatment: 11.16±6.88 years; average TCD4+ lymphocyte (LTCD4+) count on last evaluation: 593.98±392.55 cells/µL; 38 in AIDS stage). From the moment of diagnosis until July 2014, several classic CVRF have been studied: age, sex, smoking, obesity, dyslipidemia, diabetes, hypertension and global cardiovascular risk (CVR) estimated with Framingham score. The results were correlated with: antiretroviral treatment (ART), the number of ART combinations, LTCD4+ and hepatitis B (HBV) coinfection. For statistical analysis the Student and Mann-Whitney tests were used with 95% confidence interval and statistical significance p<0.05.


CVRF: hypertriglyceridemia, 29 patients (22 in stage C), decreased high-density lipoproteins (HDL) 23 (elevated, 10), hypercholesterolemia 12, elevated low-density lipoprotein (LDL) 7, smoking habit 16, obese 3, overweight 5, underweight 8, hypertension 2, diabetes 1. The Framingham test global scores: 6 moderate, 1 elevated, 43 decreased. A significant statistical difference can be observed between the initial and final values of: total cholesterol (TC), LDL and triglycerides (TG) p=0.0002, p=0.0495, p=0.0002. Patients with ≥3 combinations of ART had a significantly larger average value of TC, LDL and TG (p=0.030, p=0.041, p=0.027) compared to those with 1 combination.

Significant statistical differences are registered between: average TC and TG values (p=0.0001 p=0.0013) depending on the treatment with or without protease inhibitors (PI); between HDL values for patients with LTCD4+ ≥500 cells/µL and those with TCD4+ <500 cells/µL (p=0.028). Average TG values were significantly higher for HBV coinfections (p=0.0349).


The most frequent CVRF were: hypertriglyceridemia (58%), fall of HDL levels (46%), smoking (32%), hypercholesterolemia (24%), decreased LDL levels (14%). The lipid levels are influenced by: type of ART, number of combinations, presence of HBV and the advanced stage of disease. High levels of LTCD4+ and HDL can be considered protective factors. Because of the existence of these risks, the initiation of a program for the reduction of cardiovascular risks is necessary.

Authors’ Affiliations

Clinic of Infectious Diseases I, University of Medicine and Pharmacy Tîrgu Mureş, Romania
County Hospital Laboratory, University of Medicine and Pharmacy Tîrgu Mureş, Romania
University of Medicine and Pharmacy Tîrgu Mureş, Romania


© Zaharia-Kézdi et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.