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Table 1 Reported efficacy of azithromycin for treatment of Salmonella Typhi and Salmonella Paratyphi

From: Case report: failure under azithromycin treatment in a case of bacteremia due to Salmonella enterica Paratyphi A

Author, year Country Patients population Azithromycin dose Body weights of patients (kg) Route of administration Efficacy MIC of isolates, g/L* References
Girgis, 1999 Egypt n = 36, mean age (range): 19.6 (18–30) 1 g/day on the first day, followed by 500 mg/day on the next 6 days NA Oral Clinical cure rate: 100% BMD, MIC*90 (range): 8 (4–16) [9]
Butler, 1999 India n = 42, mean age (range): 26.2 (17–53) 500 mg/day for 7 days Mean 52.2 (range: 40–74) Oral Clinical cure rate: 88% (within 8 days), 100% (within 14 days) BMD MIC*90 (range): 16 (4–32) [7]
Chinh, 2000 Vietnam n = 44, mean age (range): 26.6 (15–68) 1 g/day for 5 days Mean 47.3 (range: 34–60) Oral Clinical cure rate: 95.5% E-test, MIC90 (range): 8 (4–16) [10]
Parry, 2007 Vietnam n = 62, mean age (range): 10.5 (4–42) 10 mg/kg/day for 7 days Mean 24 (range: 12–58) Oral Clinical cure rate: 82% E-test MIC90 (range): 16 (4–32) [8]
Dolecek, 2008 Vietnam n = 142, median age 11 yrs, (range 1–41) 20 mg/kg/day for 7 days Median 24.5 (9.5–57) Oral Treatement failure: 9.3% E-test, MIC90 (range): 12 (4–16) [11]
  1. Abbreviations: BMD broth microdilution, MIC Minimum inhibitory concentrations, NA data not available.
  2. *MIC90 were determined based on the data provided in refeneces.