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Table 4 Determinants of clearance for the most prevalent HR-HPV types

From: Persistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women: a follow-up study

Time independent variables HPV-16 HPV-18 HPV-45 HPV-58
   Multivariable model HR (95% CI) Multivariable model HR (95% CI) Multivariable model Tm R (95% CI) Multivariable model Tm R (95% CI)
Age >50 0.99 (0.53-1.86) 0.59 (0.18-1.87) 1.13 (0.63-2.02) 0.94 (0.63-1.38)
  35-50 1.14 (0.66-1.96) 0.79 (0.35-1.75) 0.77 (0.49-1.20) 1.26 (0.89-1.79)
  <35 Reference Reference Reference Reference
City Other city 2.58 (1.51-4.4) 1.21 (0.51-2.9) 0.97 (0.62-1.52) 1.79 (1.33-2.39)
  Bogota Reference Reference Reference Reference
Ethnicity Afrodescendant 2.35 (0.69-7.93) 0.85 (0.11-6.61) 0.42 (0.16-1.12) -
  Mestizo Reference Reference Reference Reference
  Other* - - - 1.17 (0.47-2.89)
Contraceptive method No method 1.01 (0.65-1.59) 0.75 (0.33-1.73) 0.84 (0.56-1.27) 0.98 (0.73-1.30)
  Hormonal 1.45 (0.72-2.96) 1 (0.35 -2.9) 0.76 (0.45-1.26) 0.97 (0.54-1.72)
  Other Reference Reference Reference Reference
Lifetime sexual partners 1 1.24 (0.83-1.86) 1.2 (0.61-2.51) 1.05 (0.72-1.52) 1.10 (0.84-1.44)
  >1 Reference Reference Reference Reference
Age at first Intercourse ≥18 0.93 (0.6-1.41) 1.08 (0.53-2.19) 1.23 (0.85-1.77) 1.13 (0.85-1.51)
  <18 Reference Reference Reference Reference
Coinfection Yes 0.87 (0.46-1.65) 2.49 (0.54-11.45) 1.06 (0.46-2.45) 0.87 (0.58-1.32)
  No Reference Reference Reference Reference
Viral Load** Low 2.1 (0.87-5.15) 0.48 (0.08-2.93) 1.27 (0.76-2.12) 1.36 (0.81-2.29)
  Middle 1.49 (0.64-3.51) 0.74 (0.24-2.27) 1.61 (1.01-2.57) 1.04 (0.61-1.78)
  High Reference Reference Reference Reference
  1. *Since only 2 women of other ethnicity had HPV-58 (1 Afrodescendant and 1 Indigenous) they were put in a category “Other”, just for this type.
  2. **Low viral load meant a viral load below 9.99E + 5, middle 1.00E + 6 to 9.99E + 9 and high meant a viral load higher than 1.00E + 10.
  3. Values in bold = p < 0.05.
  4. HPV Human papillomavirus, CI Confidence interval, HR Hazard ratio, Tm R Time ratio.