You are viewing the site in preview mode

Skip to main content

Advertisement

Table 4 HCV HVR1 genetic characteristics in responders and non-responders to PEG-IFN α and ribavirin treatment

From: Deep sequencing of hepatitis C virus hypervariable region 1 reveals no correlation between genetic heterogeneity and antiviral treatment outcome

  Responders Non-responders P
Number of patients 12 13 -
HVR1 complexity (number of haplotypes)    
≥5% 4.4 5.3 NS
≥2% 8.2 8.8 NS
≥1% 13.4 11.3 NS
Mean Shannon entropy    
≥5% 1.28 1.37 NS
≥2% 1.72 1.73 NS
≥1% 2.01 1.87 NS
Mean nucleotide diversity per nucleotide    
≥5% 0.132 0.148 NS
≥2% 0.118 0.123 NS
≥1% 0.114 0.112 NS
Mean genetic distance    
≥5% 0.187 0.203 NS
≥2% 0.145 0.160 NS
≥1% 0.135 0.164 NS
Number of nucleotide substitutions within HVR1    
≥5% 42.8 47.6 NS
≥2% 49.0 52.9 NS
≥1% 59.2 58.4 NS
Percentage of polymorphic amino acid positions    
≥5% 59.3 60.0 NS