Heterogeneity parameters of hypervariable region 1 population in responders and non-responders to treatment. The figure reports the distribution of several parameters describing the heterogeneity of the viral population assessed on hypervariable region 1 by means of massively parallel sequencing and reconstruction of the haplotypes. The results are reported by only considering variants of ≥1%, ≥2% and ≥5% frequency. The horizontal lines, boxes and whiskers indicate the median, IQR (inter-quartile range) and the values within 1.5 × IQR, respectively. Open triangles represent mean values. R- responders, NR – non-responders to treatment, NS-not significant.