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Table 1 Demographics characteristics, HIV disease status and laboratory results

From: Inflammatory, procoagulant markers and HIV residual viremia in patients receiving protease inhibitor monotherapy or triple drug therapy: a cross-sectional study

  Triple therapy (n = 74) Monotherapy (n = 72) p-value
Receiving darunavir/ritonavir. N (%) 19 (26) 27 (37.5) 0.124
Receiving abacavir. N (%) 12 (16.2) NA  
Receiving tenofovir. N (%) 60 (81.0) NA  
Receiving zidovudine. N (%) 2 (2.7) NA
Receiving lamivudine. N (%) 20 (27.0) NA
Receiving emtricitabine. N (%) 54 (72.9) NA
Male. N (%) 52 (70.3) 52 (72.2) 0.794
Age. Median (IQR) 44 (40–48) 47 (44–51) 0.002
Prior medical disease*. N (%) 27 (36.5) 36 (50) 0.099
Hepatitis C active. N (%) 18 (24.3) 14 (19.4) 0.932
AIDS. N (%) 47 (63.5) 44 (61.1) 0.764
CD4 nadir (cells/μL). Median (IQR) 141 (47–244) 172 (53–268) 0.376
Current CD4 (cells/μL). Median (IQR) 576 (417–805) 623 (457–834) 0.225
Years virologically suppressed.    
   Median (IQR) 4.7 (2.9–8.9) 7.1 (4.5–8.9) 0.019
   Monotherapy NA 2.6 (1.9–3.9)  
Patients with a single blip **. N (%) 8 (10.8) 4 (5.5) 0.249
Detectable HIV RNA (Ultrasensitive assay). N (%) 33 (44.6) 28 (38.9) 0.484
HIV RNA 20–49 copies/ml. N (%) 12 (16.2) 5 (6.9) 0.081
Triglycerides (mg/dL). Median (IQR) 149 (111–196) 189 (137–248) 0.007
LDL Cholesterol. Median (IQR) 125 (107–153) 132 (110–156) 0.161
Total Cholesterol/HDL ratio. Median (IQR) 3.8 (3.3–4.7) 4.6 (3.7–5.6) 0.003
Total Cholesterol/LDL ratio. Median (IQR) 1.6 (1.5–1.8) 1.6 (1.5–1.8) 0.668
Receiving statins. N (%) 17 (25.4) 16 (24) 0.484
HOMA index. Median (IQR) 1.7 (1.0–2.7) 2.1 (1.3–3.4) 0.105
CRP level(mg/L).Median (IQR) 0.9 (0–2.4) 1.3 (0–2.8) 0.478
CRP ≥5 mg/L. N (%) 5 (6.8) 10 (14.5) 0.139
IL-6 (pg/ml).    
   Median(IQR) 1.9 (1.2–3.4) 1.7 (1.3–3) 0.504
   IL-6 ≥ 3 pg/ml. N (%) 17 (23) 18 (25) 0.774
Fibrinogen (mg/dl). Median (IQR) 386 (351–452) 398 (362–447) 0.372
D-dimer (ng/ml). Median (IQR) 131 (99–214) 137 (99–234) 0.769
  1. Medical disease: hypertension, dyslipaemia, diabetes mellitus, ischemic heart disease, heart insufficiency, chronic renal failure, thyroid disorders and peripheral arterial disease*. Blip: detection of RNA-HIV > 50 copies/ml in the last year**. NA: non applicable.