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Table 3 HLA-A, -B, -C, -DRB1 and -DQB1 types in patients with hypothyroidism

From: Common subclinical hypothyroidism during Whipple’s disease

HLA type Number of individuals Cohort vs. control
Locus Allele Hypothyroidism Control Odds Ratio P 1
HLA-A 01 0 0% 36 28% N.A 0.19
02 5 71% 55 42% 3.41 > 0.2
03 2 29% 32 25% 1.23  
24 2 29% 26 20% 1.60  
26 1 14% 11 8% 1.80  
29 1 14% 14 11% 1.38  
32 1 14% 18 14% 1.04  
68 2 29% 14 11% 3.31 0.19
Total 7   130    
HLA-B 07 1 14% 19 15% 0.97  
14 2 29% 12 9% 3.93 0.15
15 2 29% 20 15% 2.20  
27 1 14% 8 6% 2.54  
35 1 14% 20 15% 0.92  
38 1 14% 5 4% 4.17 > 0.2
39 1 14% 6 5% 3.44 > 0.3
41 1 14% 4 3% 5.25 > 0.2
44 2 29% 34 26% 1.13  
51 1 14% 15 12% 1.28  
55 1 14% 8 6% 2.54  
Total 7   130    
HLA-C 03 3 43% 26 20% 3.00 0.16
04 1 14% 22 17% 0.82  
05 2 29% 21 16% 2.08  
06 1 14% 26 20% 0.67  
07 3 43% 66 51% 0.73  
08 2 29% 13 10% 3,60 0,17
12 1 14% 18 14% 1,04  
15 1 14% 7 5% 2,93  
Total 7   130    
HLA-DRB1 01 2 25% 27 21% 2,29  
03 1 13% 24 19% 0,63  
04 2 25% 36 28% 0,87  
07 1 13% 19 15% 0,83  
08 1 13% 9 7% 1,92  
11 3 38% 36 28% 1,57  
13 3 38% 38 29% 1,45  
14 1 13% 13 10% 1,29  
15 1 13% 24 19% 0,63  
Total 8   130    
HLA-DQB1 02 2 25% 37 29% 0,84  
03 4 50% 93 72% 0,40 > 0.2
04 1 13% 5 4% 3,57 > 0.3
05 4 50% 48 37% 1,71  
06 3 38% 56 43% 0,79  
Total 8   130    
  1. Odds ratios ≥3 are highlighted in light gray, and odds ratios <0.5 are highlighted in dark gray.
  2. 1: Two-tailed Fisher Exact Test.