You are viewing the site in preview mode

Skip to main content

Advertisement

Table 6 Sensitivity analysis exploring the influence of the degree of Influenza B lineage cross protection L

From: 4Flu - an individual based simulation tool to study the effects of quadrivalent vaccination on seasonal influenza in Germany

L Influenza B Prevented infections
No vaccination TIV QIV QIV-TIV %
0% 8283 6552 4372 2180 17,9
(8224–8394) (6477–6627) (4313–4431) (2142–2217) (17,6-18,2)
10% 7557 5760 4009 1751 15,4
(7491–7649) (5692–5827) (3954–4063) (1716–1786) (15,1-15,7)
20% 6961 5140 3772 1368 12,7
(6890–7037) (5079–5200) (3720–3824) (1336–1399) (12,5-13,0)
30% 6491 4624 3574 1050 10,2
(6445–6587) (4569–4680) (3526–3623) (1020–1080) (10,0-10,5)
40% 6144 4216 3386 830 8,4
(6070–6206) (4163–4269) (3339–3433) (801–859) (8,1-8,7)
50% 5837 3865 3276 589 6,2
(5783–5916) (3815–3914) (3230–3322) (562–615) (5,9-6,5)
60% 5229 3346 2951 395 4.3
(5183–5275) (3313–3379) (2920–2982) (376–414) (4.1-4.5)
  1. Average annual results (with 95% confidence intervals) obtained for the 20 year evaluation period (calculated from 1,000 simulations for each combination of L and vaccination strategy in a simulated population of about 80,000 individuals (2,000 simulations each for the baseline parameter value L = 60%; boldface line). The last column shows what percentage of all influenza A and B infections which occur under TIV vaccination can additionally be prevented by QIV.