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Table 5 Predictors of treatment interruption (compared to cures) (n = 457) †

From: Predictors of pulmonary tuberculosis treatment outcomes in South Korea: a prospective cohort study, 2005-2012

Variable Univariate Multivariate‡
   OR 95% CI OR 95% CI
Gender Female 1   1  
  Male 1.48 0.79-2.78 1.53 0.78-3.00
Age 20-34 1   1  
  35-49 1.16 0.69-1.95 0.92 0.53-1.59
  ≥50 0.67 0.38-1.18 0.63 0.34-1.16
Body Mass Index (n = 446) <18.5 1   -  
  ≥18.5 0.78 0.51-1.91   
Diabetes No 1   -  
  Yes 1.56 0.95-2.56   
Alcohol, within 6 months Less than once a week 1   -  
  Several times a week 1.71 0.96-3.05   
  At least once a day 2.03** 1.27-3.24   
Smoking, within 6 months Never smoked 1   -  
  < 1 pack/day 2.68** 1.31-5.49   
  1 pack/day 3.36*** 1.75-6.46   
  > 1 pack/day 3.12** 1.54-6.32   
Residence Small city and town 1   -  
  Large city 1.20 0.79-1.83   
Education High school, above 1   -  
  Middle school, below or refusal 1.20 0.80-1.82   
Occupation Unemployment and others 1   1  
  Health care, professional and office work 1.14 0.47-2.75 0.89 0.35-2.25
  Service sector and laborer 2.39** 1.45-3.95 2.30** 1.36-3.90
Chest X-ray      
Grade Minimal or moderate 1   -  
  Far advanced 1.34 0.89-2.04   
Cavity No 1   -  
  Yes or not clear 1.04 0.63-1.69   
Nodular lesion No 1   -  
  Yes or not clear 2.07 0.70-6.14   
Bilateral Unilateral 1   1  
  Bilateral 2.86** 1.46-5.60 2.46* 1.22-4.95
Number of previous treatment episode 0 (new case) 1   -  
  1 1.54 0.87-2.71   
  2 2.77** 1.53-5.02   
  ≥3 2.40** 1.35-4.27   
History of failure No 1   1  
  Yes 1.81* 1.12-2.92 1.76* 1.04-2.98
History of TI No 1   1  
  Yes 2.72*** 1.77-4.18 2.35*** 1.49-3.70
Elevation of total bilirubin No 1    
  Yes 0.63* 0.40-1.00   
Elevation of liver enzyme No 1    
  Yes 0.95 0.55-1.65   
Number of significant regimen changes 0 1   -  
  ≥1 1.62* 1.04-2.55   
Drug susceptibility pattern (n = 403) DS 1   -  
  Mono/poly-R 1.25 0.66-2.39   
  Rif, mono-R 2.01 0.68-5.92   
  MDR 1.45 0.88-2.39   
  1. *p <0.05, **p <0.01, ***p < 0.001.
  2. †Treatment interruption (n = 122) was compared with cured (n = 335).
  3. ‡Multivariate model includes age, gender and all significant factors from the univariate model.
  4. TI: Treatment interruption, DS: Drug susceptible, Mono/poly-R: mono or poly-drug resistance that is not matched with the definition of multidrug-resistant tuberculosis or rifampin mono resistance; MDR: multidrug-resistant tuberculosis.