You are viewing the site in preview mode

Skip to main content

Advertisement

Table 4 Predictors of unfavorable outcome (compared to cure) assessed at the end of study (n = 392) †

From: Predictors of pulmonary tuberculosis treatment outcomes in South Korea: a prospective cohort study, 2005-2012

Variable Univariate Multivariate‡
   OR 95% CI OR 95% CI
Gender Female 1   1  
  Male 1.29 0.70-2.35 1.14 0.59-2.20
Age 20-34 1   1  
  35-49 1.96* 1.07-3.57 2.14* 1.11-4.14
  ≥50 2.75** 1.50-5.05 2.97** 1.51-5.86
Body Mass Index <18.5 1   1  
  ≥18.5 0.47** 0.31-0.73 0.33*** 0.20-0.54
Diabetes No 1   1  
  Yes 2.47*** 1.51-4.05 2.57** 1.46-4.52
Alcohol, within 6 months Less than once a week 1   -  
  Several times a week 0.52 0.26-1.05   
  At least once a day 0.92 0.58-1.48   
Smoking, within 6 months Never smoked 1   -  
  < 1 pack/day 1.71 0.99-2.97   
  1 pack/day 1.14 0.66-1.97   
  > 1 pack/day 1.03 0.57-1.89   
Residence Small city and town 1   -  
  Large city 1.19 0.78-1.83   
Education High school, above 1   -  
  Middle school, below or refusal 1.40 0.92-2.15   
Occupation Health care, professional and office work 1   -  
  Service sector and laborer 1.35 0.66-2.76   
  Unemployment and others 1.54 0.73-3.24   
Chest X-ray      
Grade Minimal or moderate 1   -  
  Far advanced 2.09** 1.35-3.24   
Cavity No 1   -  
  Yes or not clear 1.25 0.72-2.15   
Nodular lesion No 1   -  
  Yes or not clear 1.44 0.60-3.48   
Bilateral Unilateral 1   -  
  Bilateral 2.67** 1.38-5.18   
Number of previous treatment episodes 0 (new case) 1   -  
  1 1.7 0.90-3.22   
  2 1.04 0.48-2.27   
  ≥3 4.66*** 2.69-8.08   
History of failure No 1   -  
  Yes 3.32*** 2.11-5.22   
History of TI No 1   -  
  Yes 2.26*** 1.45-3.51   
Number of significant regimen changes 0 1   -  
  ≥1 1.21 0.75-1.93   
Drug Susceptibility pattern (n = 401) DS 1   1  
  Mono/poly-R 1.42 0.68-2.97 1.45 0.67-3.13
  Rif, mono-R 1.69 0.42-6.87 2.87 0.64-12.95
  MDR 3.39*** 2.09-5.50 4.51*** 2.64-7.68
  1. *p <0.05, **p <0.01, ***p < 0.001.
  2. † Favorable outcome is cured (n = 267) and unfavorable outcome includes failure (n = 22), death (n = 86) and relapse (n = 17) assessed at the end of study.
  3. ‡ Multivariate model includes age, gender and all significant factors from the univariate model.
  4. TI: treatment interruption; DS: Drug susceptible, Mono/poly-R: mono or poly-drug resistance that is not matched with the definition of multidrug-resistant tuberculosis or rifampin mono resistance; MDR: multidrug-resistant tuberculosis.