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Table 2 Comparisons of treatment-course related characteristics of study population at the end of therapy by new or previously treated status (n = 669)

From: Predictors of pulmonary tuberculosis treatment outcomes in South Korea: a prospective cohort study, 2005-2012

Variables (n) New case Previously treated case P-value
Number of significant regimen change    
 0 194 (86.6) 311 (69.9) <0.001
 ≥1 30 (13.4) 134 (30.1)  
Elevation of total bilirubin    
 No 143 (63.8) 307 (69.0) 0.180
 Yes 81 (36.2) 138 (31.0)  
Elevation of liver enzyme    
 No 181 (80.8) 365 (82.0) 0.701
 Yes 43 (19.2) 80 (18.0)  
Months to treatment completion, median (IQR) 9.45 (8.89-12.23) 14.97 (9.67-26.10) <0.001†
Treatment outcome at EOT    
 Cured 154 (68.8) 181 (40.7) <0.001*
 Failure 4 (1.8) 61 (13.7)  
 TI 35 (15.6) 87 (19.6)  
 Unknown 15 (6.7) 50 (11.2)  
 Death 6 (2.7) 44 (9.9)  
 Withdrawal 10 (4.5) 22 (4.9)  
Culture positivity (since enrollment)    
 Converted prior to 6 months 145 (64.7) 245 (55.1) 0.001
 Positivity at 6 months, over 14 (6.2) 71 (16.0)  
 Unknown 6 month result 65 (29.0) 129 (29.0)  
 Months to TI, median (IQR) 7.98 (5.02-10.32) 9.67 (6.60-17.83) 0.013†
  1. *Tested by Fisher’s exact test.
  2. † Tested by Mann-Whitney test.
  3. AFB: Acid fast bacilli; IQR: Interquartile range; EOT: End of therapy; TI: Treatment interruption.