ELISA titer (2n) of IgG antibodyb(6 months after the last immunization)
Protection against SGV challenge
Survival mice/total mice
8.0 ± 0.8
9.5 ± 1.0d
11.7 ± 0.5d
12.3 ± 0.6d
aMice were immunized by i.p. injection twice, 3 weeks apart, with 4 μg of the inactivated vaccine with or without an adjuvant (MF59, alum, or chitosan). Mice were challenged with a lethal dose of SG-MCMV 6 months after the last immunization. Serum samples from the immunized mice were collected 2 days prior to challenge. The survival of mice 3 weeks after the challenge was measured.
bValues represent means ± SD of each group.
cSignificant difference (p < 0.05), compared with control.
dSignificant difference (p < 0.05), compared with the corresponding adjuvant-free subjects.