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Table 2 Survival after lethal SG-MCMV challenge in mice immunized intraperitoneally with various doses of inactivated vaccine with or without adjuvant a

From: An adjuvanted inactivated murine cytomegalovirus (MCMV) vaccine induces potent and long-term protective immunity against a lethal challenge with virulent MCMV

Immunogen Protection against SGV challenge (Survival mice/total mice) by various doses of FI-MCMV immunization
- 0.25 μg 1 μg 4 μg
Adjuvant-free 0/6 0/6 0/6 2/6
+ Chitosan 0/6 0/6 2/6 6/6*
+ Alum 0/6 0/6 4/6 6/6*
+ MF59 0/6 5/6* 6/6* 6/6*
Mock 0/6 - - -
PBS 0/6 - - -
  1. aThe mice were immunized twice, 3 weeks apart, with various doses (0.25, 1, or 4 μg) of the vaccine with or without adjuvant (MF59, alum, or chitosan) by i.p. injection. The mice were challenged with a lethal dose of SG-MCMV 3 weeks after the second immunization. Mouse survival 3 weeks after challenge was measured.
  2. *Significant difference (p < 0.05), compared with control subjects.