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Aplastic crisis and transient neurological symptoms due to parvovirus B19 infection in a patient with chronic hemolytic disorder


Human parvovirus B19 is considered an important trigger of aplastic crisis in patients with chronic congenital hemolytic disorders.

Case report

We describe the case of a young adult known with hereditary microspherocytosis who presented with fever, marked agitation and confusion and a slight left hemiparesis. The cerebral imaging revealed multiple giant cystic Virchow-Robin spaces, but no other abnormalities. The complete blood counts showed pancytopenia and the peripheral blood smear revealed reticulocytopenia, confirming the diagnosis of aplastic crisis. Human parvovirus B19 infection was proven by the detection of serum DNA using PCR technique. After the initiation of packed red cells transfusion a favorable outcome was seen and his neurologic symptoms fully remitted.


Direct invasion of human parvovirus B19 may induce both aplastic crisis and acute encephalopathy in patients with hereditary spherocytosis. Human parvovirus B19 may induce aplastic crisis but also acute encephalopathy through direct invasion, although in our case the transient neurological symptoms were rather an effect of hypoxia.

Author information

Correspondence to Iulia Niculescu.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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About this article


  • Pancytopenia
  • Peripheral Blood Smear
  • Direct Invasion
  • Hereditary Spherocytosis
  • Important Trigger