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Table 1 Characteristics of severe and non-severe leukopenia in a French cohort of 148 patients with S. aureus- necrotizing pneumonia, between 1986 and 2010

From: Severe leukopenia in Staphylococcus aureus-necrotizing, community-acquired pneumonia: risk factors and impact on survival

Variables Group 1 Group 2 Pvalue
  (≤3.000 leukocytes/mL) n=62 (>3 000 leukocytes/mL) n=86  
Demographic information    
Age    
0-30 32 (51.6) 55 (64.0) 0.132
>30 30 (48.4) 31 (36.0)  
Gender, M:F (ratio) 29:33 (46.8) 59:27 (68.6) 0.008
Medical history    
Smoking 7 (12.5) 16 (19.5) 0.278
Alcohol 1 (1.7) 3 (3.7) 0.479
Steroid treatment 2 (3.3) 7 (8.3) 0.222
Respiratory failure 0 (0) 3 (3.5) 0.138
Personal history of furuncles or skin abscess 1 (2.0) 12 (16.0) 0.011
Before hospital admission
Period between onset of symptoms and admissiona 3 (2-4) 3 (2-5) 0.684
Influenza-like illness 46 (79.3) 41(49.4) <0.001
SSTIb 6 (9.7) 27 (31.4) 0.002
Clinical features within the first 48 h of hospitalization  
PRISM scorea, b 27 (20-35) 6 (4-11) <0.001
SAPS II scorea, b 67 (39-80) 28 (15-61.8) <0.001
Platelet count/mL 92,000 (46,500-176,500) 204,000 (145,000-370,000) <0.001
Fever, temperature >39°C 46 (64.2) 70 (81.4) 0.294
Generalized rash 24 h 5 (8.3) 6(7.0) 0.760
Airway hemorrhage 39 (62.9) 20 (23.3) <0.001
Pleural effusion 16 (27.1) 49 (57.6) <0.001
Radiological consolidation    0.001
Unilobar 6 (9.8) 30 (34.9)  
Multilobar 48 (78.7) 44 (51.2)  
ARDSb 47 (77.0) 15 (18.1) <0.001
Methicillin resistance (mecAgene) 15 (24.2) 20 (23.3) 0.895
Treatment and outcome
Mechanical ventilation 57 (91.9) 37 (43.0) <0.001
Inotrope drugs 52 (91.2) 21 (26.3) <0.001
Time to deatha 2 (1-6) 2 (1-2.75) 0.216
Appropriate antibiotics introduced in first 24 h of h hospitalization 46 (75.4) 65 (75.6) 0.161
Mortality 47 (75.8) 14 (16.3) <0.001
Percentage of deaths attributed to S. aureus infection 47 (100) 13 (92.9) 0.065
  1. aContinuous variables are indicated as median, first and third quartiles and categorical variables as number (%).
  2. bSSTI: skin and soft tissue infection, PRISM: Pediatric Risk of Mortality; SAPS II: Simplified Acute Physiology Score; ARDS: acute respiratory distress syndrome.