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Table 2 All possible combinations of the six clinical and laboratory variables, along with the respective linear correlation coefficient (R 2 ) and its significance (P value), when correlated with CDI cure for patients in the 003 trial database with available values for all analyzed variables; n=515

From: Derivation and validation of a simple clinical bedside score (ATLAS) for Clostridium difficile infection which predicts response to therapy

  R2 P value   R2 P value
Single variables    Four variables   
Ag 0.91 0.195 Ag, Tr, Te, S * 0.92 <0.001
Tr 1.0 N/A Ag, Tr, Te, Al 0.79 0.001
Te 0.95 0.147 Ag, Tr, Te, L 0.89 <0.001
L 1.0 0.025 Ag, Tr, Al, S 0.82 <0.001
Al 0.99 0.070 Ag, Tr, L, S 0.25 0.175
S 0.47 0.518 Ag, Tr, L, Al 0.75 0.001
    Ag, Te, Al, S * 0.95 <0.001
Two variables    Ag, Te, L, S 0.78 0.008
Ag, Tr 0.78 0.048 Ag, Te, L, Al * 0.91 <0.001
Ag, Te 0.84 0.011 Ag, L, Al, S 0.87 0.001
Ag, S 0.49 0.191 Tr, Te, Al, S 0.79 0.001
Ag, Al * 0.97 0.003 Tr, Te, L, S 0.82 0.001
Ag, L 0.68 0.087 Tr, Te, L, Al 0.86 0.003
Tr, Te 0.79 0.044 Tr, L, Al, S 0.65 0.016
Tr, S 0.70 0.077 Te, L, Al, S * 0.91 <0.001
Tr, Al 0.84 0.030    
Tr, L 0.26 0.375 Five variables   
Te, S 0.06 0.702 Ag, Tr, Te, Al, S 0.80 <0.001
Te, Al * 0.92 0.002 Ag, Tr, Te, L, S 0.82 0.002
Te, L 0.89 0.058 Ag, Tr, S, L, Al ** 0.95 <0.001
Al, S 0.90 0.015 Ag, Te, L, Al, S 0.78 0.001
L, S 0.63 0.108 Ag, Tr, Te, L, Al 0.86 <0.001
L, Al * 0.94 0.006 Tr, Te, L, Al, S 0.79 0.001
Three variables    Six variables   
Ag, Tr, Te 0.85 0.003 Ag, Tr, Te, L, Al, S 0.70 0.001
Ag, Tr, S 0.86 0.003    
Ag, Tr, Al 0.86 0.003    
Ag, Tr, L * 0.96 <0.001    
Ag, Te, S * 0.98 0.001    
Ag, Te, Al 0.83 0.002    
Ag, Te, L * 0.90 0.001    
Ag, Al, S 0.86 0.002    
Ag, L, S 0.10 0.482    
Ag, L, Al 0.810 0.002    
Tr, Te, S 0.82 0.005    
Tr, Te, Al; 0.82 0.002    
Tr, Te, L 0.71 0.036    
Tr, Al, S 0.84 0.004    
Tr, L, S 0.00 0.975    
Tr, L, Al 0.49 0.081    
Te, Al, S 0.17 0.366    
Te, L, S 0.84 0.029    
Te, L, Al * 0.95 <0.001    
L, Al, S 0.79 0.003    
  1. All combinations meeting the pre-set “acceptable” criteria (R2 ≥ 0.9 and P ≤ 0.01) are marked with an asterisk (*), and the single combination among this latter group which was composed of the largest number of variables is marked with a double asterisk (**) as the optimal scoring system.
  2. Ag = age; Tr = treatment with systemic antibiotics; Te = temperature; L = leukocyte count (total); Al = serum albumin; S = serum creatinine as a measure of renal function.
  3. CDI: Clostridium difficile infection.
  4. N/A: not applicable.