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Table 3 Frequency distribution of mutations across rpoB, katG and inhA genes

From: Drug resistance mutations and heteroresistance detected using the GenoType MTBDRplusassay and their implication for treatment outcomes in patients from Mumbai, India

Pattern rpoB katG inhA n (onset) n (5th month)
Only INH (n = 22) - - A16G mixed 6 1
  - S315T1 - 3 1
  - - ΔWT2 2 0
  - - C15T 2 0
  - S315T1, T2 - 2 0
  - S315T1, T2 mixed - 2 0
  - S315T1, T2 A16G mixed 1 0
  - S315T1 mixed - 1 0
  - S315T1, T2 mixed A16G mixed 1 0
Only RIF (n = 4) Δ WT8 - - 1 1
  ΔWT6, 7, 8 - - 0 1
  D516V mixed - - 1 0
MDR (n = 82) ΔWT8 S315T1, T2 mixed - 2 11
  D516V mixed - A16G mixed 4 5
  ΔWT8 - ΔWT2 1 6
  ΔWT8 - A16G mixed 3 4
  S531L S315T1 - 1 4
  D516V mixed, ΔWT8 - A16G mixed 0 4
  S531L S315T1, T2 mixed - 1 3
  D516V mixed, S531L S315T1, S315T2 - 0 3
  ΔWT8 S315T2 mixed - 1 1
  ΔWT7, 8 - ΔWT2 0 2
  D516V mixed, ΔWT8 S315T1, T2 mixed A16G mixed 0 2
  D516V mixed, ΔWT8 S315T1, T2 mixed - 0 2
  D516V mixed S315T1, S315T2 A16G mixed 1 1
  ΔWT8 S315T1, S315T2 - 0 1
  ΔWT4 S315T1, S315T2 - 1 0
  ΔWT8 - C15T mixed 0 1
  ΔWT8 S315T1 mixed - 0 1
  ΔWT7 - ΔWT2 0 1
  ΔWT6, 7, 8 - ΔWT2 0 1
  ΔWT1, 6, 8 - A16G mixed 0 1
  H526Y S315T1, S315T2 - 0 1
  S531L S315T1, S315T2 C15T 1 0
  S531L S315T1, S315T2 - 1 0
  D516V mixed, S531L S315T1, T2 mixed - 1 0
  D516V mixed, S531L S315T1, S315T2 A16G mixed 1 0
  D516V mixed, S531L - C15T 0 1
  S531L S315T1, S315T2 A16G mixed 0 1
  S531L - A16G mixed 0 1
  D516V mixed, S531L S315T1, T2 mixed A16G mixed 0 1
  D516V mixed, S531L S315T2 mixed - 0 1
  D516V mixed, S531L - A16G mixed 0 1
  D516V mixed S315T1, S315T2 - 1 0
  S531L mixed S315T1, T2 mixed A16G mixed, T8A 0 1