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Table 1 Data Used

From: Dose-response model of murine typhus (Rickettsia typhi): time post inoculation and host age dependency analysis

Pathogen/strain Study/Reference Mode of inoculation Test animal/Response Organism/Reponses end point Dose Number of Test Animals Positive Responses Negative Responses
R. typhi (Wilmington) [10] s.c. BALB/c mice (sero-conversion on day 9) 0.01(PFU) 10 0 10
     0.1 10 0 10
     1 10 0 10
     10 10 0 10
     100 10 0 10
     1000 10 0 10
     10000 10 10 0
R. typhi (Wilmington) [10] s.c. BALB/c mice (sero-conversion on day 12) 0.01(PFU) 10 0 10
     0.1 10 0 10
     1 10 0 10
     10 10 0 10
     100 10 7 3
     1000 10 8 2
     10000 10 10 0
R. typhi (Wilmington) [10] s.c. BALB/c mice (sero-conversion on day 15) 0.01(PFU) 10 0 10
     0.1 10 0 10
     1 10 1 9
     10 10 5 5
     100 10 9 1
     1000 10 9 1
     10000 10 10 0
R. typhi (Wilmington) [10] s.c. BALB/c mice (sero-conversion on day 21) 0.01(PFU) 10 0 10
     0.1 10 0 10
     1 10 5 5
     10 10 8 2
     100 10 9 1
     1000 10 10 0
     10000 10 10 0
R. typhi (Wilmington) [10] s.c. BALB/c mice (sero-conversion on day 28) 0.01(PFU) 10 0 10
     0.1 10 3 7
     1 10 8 2
     10 10 9 1
     100 10 10 0
     1000 10 10 0
     10000 10 10 0
R. typhi (Ethiopian) [8] i.d. Adult rat (sero-conversion) 0.0435(PFU) 5 0 5
     0.435 5 1 4
     4.35 5 5 0
     43.5 5 5 0
     435 5 5 0
     4350 5 5 0
     43500 5 5 0
R. typhi (Ethiopian) [8] i.d. Newborn rat (sero-conversion) 0.0435(PFU) 8 0 8
     0.435 8 2 6
     4.35 8 8 0
     43.5 8 8 0
     435 8 8 0
     4350 8 8 0
R. typhi (Ethiopian) [9] Oral Young rat 3 day old (sero-conversion) 10(PFU) 3 1 2
     100 6 4 2
     1000 3 3 0
     10000 3 2 1
     100000 5 5 0
R. typhi (Ethiopian) [9] Oral Young rat 7 day old (sero-conversion) 10(PFU) 3 1 2
     100 3 2 1
     1000 2 2 0
     10000 3 2 1
     100000 3 3 0
R. typhi (Ethiopian) [9] Oral Young rat 30 day old (sero-conversion) 10(PFU) 3 0 3
     100 6 1 5
     1000 3 2 1
     10000 3 2 1
     100000 3 2 1