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Table 1 Differential apoptotic gene expressions of RD cells in response to EV71 infection at 8 and 20 h postinfection

From: Differential apoptosis gene expressions of rhabdomyosarcoma cells in response to enterovirus 71 infection

Symbols Description of genes EV71/control
   (Fold changes)
   8 h 20 h
ACIN1 Apoptotic chromatin condensation inducer 1 (ACINUS; ACN; fSAP152) -3.17 1.33
AIFM1 Apoptosis-inducing factor 1 (AIF; COXPD6; PDCD8) 1.03 -1.33
AIFM2 Apoptosis-inducing factor, mitochondrion-associated, 2 (AMID; PRG3; RP11-367H5.2) -3.83 -1.25
Akt1 V-akt murine thymoma viral oncogene homolog 1 (AKT1; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA) -9.89 -1.13
Akt2 V-akt murine thymoma viral oncogene homolog 2 (AKT2, PKBB; PKBBETA; PRKBB; RAC-BETA) -3.36 2.66
Akt3 V-akt murine thymoma viral oncogene homolog 3(AKT3) -1.06 1.58
APAF1 Apoptotic peptidase activating factor 1 (APAF-1; CED4) -4.10 1.09
API5 Apoptosis inhibitor 5 (AAC-11; AAC11) -5.41 1.06
Bcl-2 B-cell lymphoma 2 (BCL-2) -1.07 -1.43
BIRC2 Baculoviral IAP repeat-containing 2 1.56 1.23
BIRC3 Baculoviral IAP repeat-containing 3 (AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49; c-IAP2) -1.84 3.19
Caspase-3 Apoptosis-related cysteine peptidase 3(Casp3) 1.91 2.38
Caspase-4 Apoptosis-related cysteine peptidase 4(Casp4) -1.31 1.15
Caspase-7 Apoptosis-related cysteine peptidase 7(Casp7) -2.15 2.03
Caspase-8 Apoptosis-related cysteine peptidase 8(Casp8) 1.87 2.17
Caspase-9 Apoptosis-related cysteine peptidase 9(Casp9) -4.98 -1.02
Caspase-10 Apoptosis-related cysteine peptidase 10(Casp10) 1.25 2.16
Caspase-12 Apoptosis-related cysteine peptidase 12 (Casp12) 1.24 1.10
CD5 CD5 molecule -2.41 4.77
CD70 CD70 molecule 1.55 4.04
CD40L CD40 ligand -2.51 5.44
CD24 CD24 molecule 1.53 2.98
CD27 CD27 molecule -2.37 1.71
c-Fos c-fos proto-oncogene 2.34 3.23
c-Jun c-Jun proto-oncogene 1.69 5.52
CIDEA Cell death-inducing DFFA-like effector a -1.32 -1.58
CIDEB Cell death-inducing DFFA-like effector b -2.67 2.98
DAPK1 Death-associated protein kinase 1 -2.80 1.24
DAPK2 Death-associated protein kinase 2 -1.81 1.32
DAPK3 Death-associated protein kinase 3 (ZIP; ZIPK) -10.17 2.06
DFFA DNA fragmentation factor subunit alpha (DFF-45; DFF1; ICAD) -2.09 -1.14
E2F1 Transcription factor E2F1 (RBAP1; RBBP3; RBP3) -3.99 -1.17
E2F2 Transcription factor E2F2 -1.64 1.55
EGFR Epidermal growth factor receptor -4.78 1.38
ENDOG Endonuclease G -11.37 1.06
ERBB3 Receptor tyrosine-protein kinase erbB-3 (ErbB-3; HER3; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3) -2.29 1.54
FADD Fas-associated protein with death domain (MORT1) -1.48 -1.42
FasL Fas ligand (FAS L, CD95L; CD178; TNFSF6) -1.14 7.53
Fas Fas receptor (ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6) -1.23 3.26
IFN-α2 Interferon alpha-2 1.13 1.54
IFN-β1 Interferon beta 5.22 1.47
IGF1 Insulin-like growth factor 1 (IGF-I; IGF1A; IGFI) -1.14 -1.15
IGF1 R Insulin-like Growth Factor 1 (IGF-1), Receptor (CD221; IGFIR; IGFR; JTK13) -3.50 1.27
IKBKB inhibitor of nuclear factor kappa-B kinase subunit beta (IKK-beta; IKK2; IKKB; NF-κBIKB) -3.52 1.33
IKBKG inhibitor of nuclear factor kappa-B kinase subunit gamma (AMCBX1; FIP3; IKK-gamma; IP1; IP2; IPD2; NEMO) -5.76 1.40
IL-10 Interleukin 10 1.10 12.15
IL-1α Interleukin-1 alpha -2.60 1.64
IL-1β Interleukin-1 beta -2.20 1.30
IL-2 Interleukin 2 1.24 12.15
IL-4 Interleukin 4 -3.72 2.39
IL-6R Interleukin 6 receptor (CD126) -5.80 1.92
IL-7 Interleukin 7 -1.65 1.26
IRAK1 Interleukin-1 receptor-associated kinase 1 -3.70 3.39
JAK2 Janus kinase 2 (JTK10; THCYT3) 1.06 -1.21
MAP3K1 Mitogen-activated protein kinase kinase kinase 1 (MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6) -4.55 1.51
MAP3K5 Mitogen-activated protein kinase kinase kinase 5 (ASK1; MAPKKK5; MEKK5) -2.39 1.99
MAP2K4 Mitogen-activated protein kinase kinase 4 (JNKK1; MAPKK4; MEK4) -1.06 2.54
MAP2K7 Mitogen-activated protein kinase kinase 7(MAPKK7; MEK7) -1.09 3.05
MAPK1 Mitogen-activated protein kinase 1 (ERK; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41) -2.21 1.00
MAPK3 Mitogen-activated protein kinase 3(ERK1; HS44KDAP; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK) -2.74 1.67
MAPK8 Mitogen-activated protein kinase 8(JNK; JNK1; SAPK1) 1.73 2.53
MAPK9 Mitogen-activated protein kinase 9(JNK2; JNK2A; JNK2B; SAPK) 1.02 2.25
MYD88 Myeloid differentiation primary response gene (88) -6.09 1.82
NF-κB1 Nuclear factor NF-kappa-B p105 subunit(NFKB-p105; NFKB-p50; NFkappaB; p105; p50) -4.81 1.18
NF-κB3 Transcription factor p65 (RELA; NF-κB p65) -1.35 2.63
NF-κBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IKBA; MAD-3; NFKBI) 1.49 2.96
NTRK1 Neurotrophic tyrosine kinase receptor type 1(MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA) -2.84 1.33
PDCD1 Programmed cell death protein 1( CD279; PD-1; hPD-l) -1.63 4.48
PDCD4 Programmed cell death protein 4 -1.30 1.06
PDCD 7 Programmed cell death protein 7 1.87 1.42
PI3K-α Phosphoinositide-3-kinase, catalytic, alpha polypeptide(PIK3CA; p110-alpha; PI3K) -1.26 1.04
PI3K-γ Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG ; PI3K; PI3Kgamma; PIK3) -1.40 5.18
PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta(P85B; p85; p85-BETA) -2.12 -1.20
PPP3R1 protein phosphatase 2B regulatory subunit 1(CALNB1; CNB; CNB1) -1.52 1.94
RIPK1 Receptor-interacting serine/threonine-protein kinase 1(RIP; RIP1) -2.44 1.24
STAT1 Signal transducers and activators of transcription (CANDF7; ISGF-3; STAT91) -6.18 4.04
STAT5A Signal transducer and activator of transcription 5A -1.14 -1.15
STAT5B Signal transducer and activator of transcription 5B -3.17 1.08
TGFB1 Transforming growth factor beta 1(CED; DPD1; LAP; TGFB; TGFbeta) -2.23 -1.15
TNF-α Tumor necrosis factors -1.97 2.19
TNFRSF10A Tumor necrosis factor receptor superfamily member 10A (APO2; CD261; DR4; TRAILR-1; TRAILR1) -2.82 2.03
TNFRSF10B Tumor necrosis factor receptor superfamily member 10B (DR5, CD262, TRICK2, TRICKB, TRAILR2, TRICK2A, TRICK2B) -2.84 1.02
P53 Tumor protein 53(LFS1; TP53; TRP53) -7.60 1.32
XIAP X-linked inhibitor of apoptosis protein(API3; BIRC4; IAP-3; ILP1; MIHA; XLP2; hIAP3) -1.94 2.59
  1. Negative values indicate down-regulation of genes.