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Table 1 IC50 values of seven extracts in P. falciparum and other microbes.

From: High content live cell imaging for the discovery of new antimalarial marine natural products

  3D7 MRSA VREF WTCA ARCA
G-0005-4 0.680 ± 0.13 NT 16.4 227 156
G-0021-3 0.790 ± 0.17 11.9 15.2 > 250 250
G-0049-4 0.916 ± 0.19 8.5 7.1 221 225
G-0335-3 0.775 ± 0.25 62.5 > 250 > 250 > 250
G-0355-3 0.131 ± 0.02 1.9 69.2 > 250 > 250
G-0488-3 0.119 ± 0.03 0.5 > 250 1.08 1.11
G-0490-3 0.163 ± 0.02 1.26 67.61 > 250 > 250
G-0494-4 0.137 ± 0.02 0.5 0.5 > 250 > 250
G-0580-3 0.0055 ± 0.01 92.26 153.11 > 250 > 250
G-0588A-3 0.847 ± 0.09 39.9 107.5 150 150
  1. Extracts are considered a 'hit' if IC50 < 100 μg/mL, and extracts with > 250 μg/mL are considered not active. IC50 values for 3D7 P. falciparum strain are significantly lower than other microbes (MRSA: methicillin-resistant Staphylococcus aureus; VREF: vancomycin- resistant Enterococcus faecium; WTCA: wild type Candida albicans; ARCA: amphotericin-B-resistant Candida albicans). NT indicates not tested, values for P. falciparum 3D7 samples are from duplicates, and the values for MRSA, VREF, WTCA, or ARCA screens are from a single experiment. Unit values are in μg/mL.