A schematic diagram of natural products antimalarial screen. Marine organisms were collected from the reef off the Fijian Islands. Extracts were aliquoted into 96-well microtiter plates and cultures were subsequently added. A SYBR Green I based assay was used as a primary screen of 2685 extracts. Extracts that inhibited P. falciparum growth were subjected to a high-content live cell imaging secondary screen.