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Table 1 Characteristics of 226 Patients Receiving Fluoroquinolone (FQ) Antibiotics

From: Unnecessary use of fluoroquinolone antibiotics in hospitalized patients

Characteristic Unnecessary (n = 70) Necessary (n = 157) P Value
Age in years-median (IQR) 65 (49, 80) 59 (45, 72) 0.045
Males 30 (43) 70 (45) 0.81
Hospitalized in previous 12 months 48 (69) 101 (64) 0.58
Antibiotics in previous 3 months 29 (41) 83 (53) 0.11
   FQ antibiotics in previous 3 months 11 (16) 33 (21) 0.35
Long-term care resident 20 (29) 36 (23) 0.38
Comorbidities    
   Diabetes 23 (33) 53 (34) 0.89
   Cancer 9 (13) 30 (19) 0.25
   Chronic neurological condition 17 (24) 28 (18) 0.26
   Dementia 12 (17) 16 (10) 0.14
Service First Prescribing FQs    
   Emergency Department 22 (31) 55 (35) 0.60
   Medicine 25 (36) 68 (43) 0.28
   Surgery 6 (9) 21 (13) 0.38
   Family Practice 8 (11) 6 (4) 0.04
   Rehabilitation Medicine 9 (13) 3 (2) 0.002
   Obstetrics/Gynecology 0 (0) 4 (3) 0.31
Indication    
   Treatment 68 (97) 150 (96) 0.73
   Prophylaxis 2 (3) 7 (4)  
Regimen    
   FQ as monotherapy 46 (66) 51 (32) < 0.001
   FQ in combination with other antimicrobials 24 (34) 106 (68)  
Syndrome    
   Urinary 36 (51) 28 (18) < 0.001
   Pulmonary 2 (3) 50 (32) < 0.001
   Upper respiratory tract 4 (6) 9 (6) 1.000
   Bacteremia 3 (4) 7 (4) 1.000
   Fever or sepsis syndrome 3 (4) 11 (7) 0.56
   Diarrhea 2 (3) 3 (2) 0.65
   Intra-abdominal 2 (3) 20 (13) 0.03
   Skin and soft tissue 4 (6) 7 (5) 0.74
   Non-infectious condition 11 (16) 18 (11) 0.39
   Other 3 (4) 4 (3) 0.68
  1. Interquartile range (IQR). Data are number of regimens (percentage of regimen category) unless otherwise indicated. Categorical data were assessed using Pearson Chi-square test or Fisher's exact test; Fisher's exact test was used for categorical data when the expected value for any given cell was less than 10.