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Table 3 Serial response to the IP-10-based and IFN-γ-based assays in patients with active TB

From: IP-10 response to RD1 antigens might be a useful biomarker for monitoring tuberculosis therapy

  QFT-IT antigens   RD1 selected peptides IFN-γ cut-off 0.57 IU/ml  
  Time points   Time points  
  T0 T6 p value T0 T6 p value
IP-10 Positive over total (%) 16/17 (94.1) 14/17 (82.3) 0.6 16/17 (94.1) 7/17 (41.1) 0.002
IFN-γ Positive over total (%) 17/17 (100) 14/17 (82.3) 0.2 16/17 (94.1) 7/17 (41.1) 0.002
IP-10 N of reversion over total (%) - 3/17 (17.6)   - 10/17 (58.8)  
IP-10 N of conversion over total (%) - 1/17 (5.8)   - 0/17 (0)  
IFN-γ N of reversion over total (%) - 3/17 (17.6)   - 9/17 (52.9)  
IFN- γ N of conversion over total (%) - 0/17 (0)   - 0/17 (0)  
  1. Footnotes: TB: tuberculosis; QFT-IT: QuantiFERON TB Gold In tube; IP: inducible protein; IFN: interferon; RD: region of difference; N: number; T0: baseline; T6: end of treatment.