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Table 2 Comparison between LC* and CC* in vitro antifungal susceptibilities of the most representative Candida species determined by Etest and Sensititre

From: Antifungal susceptibility of invasive yeast isolates in Italy: the GISIA3 study in critically ill patients

Drug Species (No of isolates) Centre Etest MIC mg/L °Agreement % Sensititre MIC mg/L °Agreement %
    Range 50% 90% EA CA Range 50% 90% EA CA
  All isolates (638) LC ≤0.002-1.5 0.19 0.5 93.1 99.4 0.015-2 0.5 1 89.9 98.6
   CC 0.032-8 0.19 0.38    0.03-2 0.5 1   
  Candida albicans (327) LC 0.002-1 0.19 0.25 96.3 100 0.015-1 0.5 1 91.1 99.4
   CC 0.032-1 0.19 0.25    0.06-1 0.5 0.5   
  Candida parapsilosis (144) LC 0.004-1.5 0.125 0.5 85.4 99.3 0.015-2 0.5 1 89.6 98.6
Amphotericin B   CC 0.032-0.75 0.19 0.25    0.03-1 0.5 0.5   
  Candida glabrata (77) LC 0.002-1.5 0.25 0.75 97.4 98.7 0.015-2 0.5 1 87 98.7
   CC 0.047-1 0.25 0.5    0.06-1 0.5 1   
  Candida tropicalis (38) LC 0.032-1.5 0.25 0.5 86.8 97.4 0.06-2 0.5 2 97.7 89.5
   CC 0.047-0.75 0.25 0.5    0.12-1 0.5 1   
  Candida krusei (15) LC 0.064-0.5 0.5 0.5 93.3 100 0.25-1 0.5 1 100 93.2
   CC 0.25-1 0.5 1    0.5-2 1 1   
  All isolates (638) LC ≤0.002-≥32 0.008 2 89.6 93 ≤0.008-≥16 0.06 1 92.5 99.7
   CC ≤0.002-≥32 0.008 1.5    ≤0.008-≥16 0.06 1   
  Candida albicans (327) LC ≤0.002-4 0.003 0.006 89.7 99 ≤0.008-1 0.03 0.06 89.6 100
   CC ≤0.002-3 0.003 0.006    ≤0.008-2 0.03 0.06   
Anidulafungin Candida parapsilosis (144) LC 0.004-≥32 1.5 4 89.2 74.1 0.03-4 1 2 97.9 98.6
   CC ≤0.002-≥32 1 2    ≤0.008-2 1 2   
  Candida glabrata (77) LC 0.003-2 0.012 0.032 92.0 100 ≤0.008-2 0.03 0.12 94.8 100
   CC 0.004-2 0.012 0.023    ≤0.015-2 0.06 0.12   
  Candida tropicalis (38) LC ≤0.002-0.064 0.016 0.032 84.2 100 ≤0.008-1 0.06 0.25 89.5 100
   CC 0.006-1.5 0.016 0.125    0.03-2 0.06 0.25   
  Candida krusei (15) LC 0.012-0.047 0.023 0.047 100 100 0.015-0.12 0.06 0.12 100 100
   CC 0.012-0.047 0.023 0.047    0.06-0.12 0.06 0.12   
  All isolates (638) LC ≤0.002-≥32 0.19 1 94.5 98.9 ≤0.008-≥16 0.12 0.5 96.7 99.8
   CC 0.012-≥32 0.19 0.75    0.015-≥16 0.12 0.5   
  Candida albicans (327) LC ≤0.002-1 0.125 0.25 94.2 100 0.008-0.5 0.06 0.12 97.9 100
   CC 0.012-1.5 0.094 0.19    0.015-1 0.06 0.12   
  Candida parapsilosis (144) LC 0.032-3 0.75 2 92.3 95.8 0.03-8 0.5 1 95.8 99.3
Caspofungin   CC 0.094-3 0.5 1    0.06-2 0.5 1   
  Candida glabrata (77) LC 0.047-2 0.25 0.38 98.7 100 0.015-≥16 0.12 0.25 97.4 100
   CC 0.125-1 0.19 0.25    0.03-≥16 0.12 0.25   
  Candida tropicalis (38) LC 0.016-0.38 0.19 0.25 94.7 100 0.03-0.5 0.06 0.25 92.1 100
   CC 0.064-2 0.19 0.5    0.03-0.5 0.06 0.25   
  Candida krusei (15) LC 0.38-1 0.75 1 100 100 0.12-1 0.5 0.5 100 100
   CC 0.38-1.5 0.5 1    0.12-0.5 0.5 0.5   
  All isolates (638) LC 0.023-≥256 0.38 12 92.2 93.2 ≤0.12-≥256 0.5 16 94.3 92.8
   CC 0.032-≥256 0.38 8    ≤0.12-≥256 0.5 16   
  Candida albicans (327) LC 0.023-≥256 0.25 0.75 92.0 99.1 ≤0.12-≥256 0.25 0.5 94.8 99.1
   CC 0.047-32 0.25 0.75    ≤0.12-32 0.25 0.5   
  Candida parapsilosis (144) LC 0.32-≥256 0.5 2 95.8 97.2 ≤0.12-128 1 4 97.2 96.7
Fluconazole   CC 0.125-32 0.5 1.5    ≤0.12-64 1 4   
  Candida glabrata (77) LC 0.38-≥256 12 ≥256 84.4 64.9 0.5-≥256 16 64 90.9 58.4
   CC 0.125-≥256 8 48    0.5-≥256 16 64   
  Candida tropicalis (38) LC 0.125-16 0.5 2 92.1 100 0.25-≥256 1 4 84.2 92.1
   CC 0.032-32 0.5 2    0.25-16 1 4   
  Candida krusei (15) LC 12-≥256 48 ≥256 86.7 46.7 8-64 32 64 100 86.7
   CC 16-128 32 64    32-64 32 64   
  All isolates (638) LC ≤0.002-≥32 0.064 1 81.3 79.4 ≤0.008-≥16 0.06 0.5 92.5 84.4
   CC 0.004-≥32 0.064 1.5    ≤0.008-≥16 0.06 0.5   
  Candida albicans (327) LC 0.002-≥32 0.047 0.25 84.1 80.4 ≤0.008-≥16 0.03 0.12 92.7 94.1
   CC 0.004-1 0.064 0.25    ≤0.008-0.25 0.06 0.12   
  Candida parapsilosis (144) LC ≤0.002-1 0.032 0.25 87.5 84.7 ≤0.008-0.5 0.12 0.12 94.4 82.7
Itraconazole   CC 0.008-3 0.032 0.38    ≤0.008-1 0.12 0.25   
  Candida glabrata (77) LC ≤0.002-≥32 1.5 ≥32 61.8 80.3 0.03-≥16 0.5 ≥16 89.6 66.2
   CC 0.004-≥32 2 ≥32    0.06-≥16 0.5 2   
  Candida tropicalis (38) LC 0.012-16 0.094 0.38 68.4 55.3 0.03-≥16 0.12 0.5 86.8 36.8
   CC 0.016-3 0.125 1    0.06-1 0.25 0.5   
  Candida krusei (15) LC 0.125-32 1 2 86.7 73.3 0.12-0.5 0.25 0.5 100 73.3
   CC 0.5-2 1 2    0.12-0.5 0.25 0.5   
  All isolates (638) LC ≤0.002-≥32 0.064 0.5 92.8 94.2 ≤0.008-≥8 0.03 0.5 91.8 96.1
   CC 0.003-≥32 0.064 0.5    ≤0.008-≥8 0.03 1   
  Candida albicans (327) LC ≤0.002-≥32 0.047 0.094 95.7 99.7 ≤0.008-≥8 0.015 0.03 90.8 98.8
   CC 0.003-0.25 0.047 0.094    ≤0.008-0.5 0.015 0.03   
  Candida parapsilosis (144) LC 0.003-0.25 0.064 0.125 98.6 99.3 ≤0.008-4 0.03 0.12 95.1 99.3
Posaconazole   CC 0.012-4 0.047 0.125    ≤0.008-1 0.06 0.12   
  Candida glabrata (77) LC 0.003-≥32 1 ≥32 66.2 57.1 ≤0.008-≥8 0.5 ≥8 90.9 77.9
   CC 0.012-≥32 1 24    0.015-≥8 1 ≥8   
  Candida tropicalis (38) LC 0.016-1.5 0.094 0.19 94.7 97.4 0.015-≥8 0.12 1 84.2 92.1
   CC 0.016-2 0.094 0.25    0.015-1 0.12 1   
  Candida krusei (15) LC 0.094-1 0.25 0.5 93.3 100 0.12-0.5 0.25 0.5 100 100
   CC 0.19-0.5 0.25 0.5    0.12-0.5 0.25 0.5   
  All isolates (638) LC ≤0.002-≥32 0.016 0.25 90.3 98.9 ≤0.008-≥16 0.008 0.25 91.5 99.0
   CC ≤0.002-≥32 0.023 0.25    ≤0.008-8 0.008 0.25   
  Candida albicans (327) LC ≤0.002-≥32 0.012 0.032 86.2 99.4 ≤0.008-≥16 ≤0.008 0.015 92.7 99.4
   CC ≤0.002-0.25 0.016 0.047    ≤0.008-0.25 ≤0.008 ≤0.008   
  Candida parapsilosis (144) LC ≤0.002-1 0.016 0.094 91.7 100 ≤0.008-1 0.015 0.12 90.3 100
Voriconazole   CC ≤0.002-1 0.016 0.094    ≤0.008-1 0.015 0.06   
  Candida glabrata (77) LC 0.004-≥32 0.25 1.5 85.7 94.8 ≤0.008-≥16 0.25 1 89.6 89.6
   CC 0.006-≥32 0.25 1.5    ≤0.008-8 0.25 1   
  Candida tropicalis (38) LC 0.016-0.5 0.047 0.125 86.8 100 ≤0.008-16 0.06 1 86.8 94.7
   CC 0.012-1 0.064 0.25    0.015-1 0.06 0.25   
  Candida krusei (15) LC 0.094-0.75 0.25 0.5 100 100 0.06-0.5 0.25 0.5 100 100
   CC 0.19-0.75 0.38 0.5    0.12-0.5 0.25 0.5   
  1. * LC = Laboratory Centre, CC = Coordinating Centre
  2. ° EA = Essential Agreement (MIC values within 2 dilutions), CA = Categorical Agreement (MIC values that fell within the same interpretive categories),