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Table 1 In vitro antifungal susceptibilities of 638 clinical yeast isolates determined by CLSI M27-A2, Etest and Sensititre

From: Antifungal susceptibility of invasive yeast isolates in Italy: the GISIA3 study in critically ill patients

Drug Method MIC values % of R strains CA% % of isolates with discrepant results
   Ranges 50% 90%    Minor Major Very major
  CLSI 0.12-2 0.5 1 2.6     
Amphotericin B Etest 0.032-8 0.19 0.38 0.2 97.5 - - 2.5
  Sensititre 0.03-2 0.5 1 0.4 97.3 - 0.2 2.5
  CLSI <0.008-≥16 0.12 16 3.6     
Anidulafungin Etest ≤0.002-≥32 0.008 1.5 3.8 94.7 - 2.1 3.2
  Sensititre ≤0.008-≥16 0.06 1 1.7 96.4 - - 3.6
  CLSI 0.016-≥16 1 2 6.7     
Caspofungin Etest 0.012-≥32 0.19 0.75 2.2 95.0 - 0.2 4.8
  Sensititre 0.015-≥16 0.12 0.5 2.2 95.3 - - 4.7
  CLSI ≤0.12-128 0.5 16 3.3     
Fluconazole Etest 0.032-≥256 0.38 8 2.2 91.1 7.7 0.2 1
  Sensititre ≤0.12-≥256 0.5 16 2.7 89.8 0.2 0.2 9.8
Itraconazole CLSI 0.008-≥16 0.25 1 7.8     
  Etest 0.004-≥32 0.064 1.5 8.9 47.7 49.2 - 3.1
  Sensititre ≤0.008-≥8 0.03 1 5.9 46.8 59.2 - 4.0
Posaconazole CLSI ≤0.008-≥8 0.12 1 6.5     
  Etest 0.003-≥32 0.064 0.5 10.6 93.4 4.8 1.6 0.2
  Sensititre ≤0.008-≥8 0.03 1 2.3 96.0 3.5 - 0.5
Voriconazole CLSI ≤0.008-8 0.016 0.25 1.9     
  Etest ≤0.002-≥32 0.023 0.25 1.4 98.8 0.9 - 0.3
  Sensititre ≤0.008-8 0.008 0.25 1.1 98.3 1.0 0.2 0.5
  1. * Categorical Agreement (MIC values that fell within the same interpretive categories)