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Table 2 Host and viral baseline parameters in patients with and without treatment response

From: Core mutations, IL28B polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infection

  SVR n = 29 non-SVR n = 21 Univariate p value
Age (mean) 45.2 48.8 0.09a
   Number of patients < 45 / > 45 yrs 11 / 18 4 / 17 0.21b
Gender (m/f) 17 / 12 13 / 8 1.0b
Baseline HCV RNA (mean log IU/mL) 6.37 6.59 0.56a
   Number with < 5.6 / > 5.6 log IU/mL 8 / 21 0 / 21 0.01b
Genotype 1a/1b 21 / 8 16 / 5 1.0b
Fibrosis (F0/F1/F2/F3/F4)c 0 / 10 / 13 / 4 / 0 2 / 4 / 4 / 7 / 2 0.19d
Core aa 70 28 R / 1 Q 15 R / 5 Q & 1 P 0.03b
Core aa 91 21 C / 6 M / 2 L 16 C / 3 M / 2 L 0.82e
rs12979860 16 CC / 13 CT / 0 TT 2 CC / 11 CT / 8 TT 0.0001e
  1. a Mann-Whitney U test.
  2. b Fisher's exact test.
  3. c Fibrosis was scored according to Ludwig and Batts, and was available for 34 patients.
  4. d Logistic regression.
  5. e Chi square test.