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Table 4 Sensitivity analyses of the CD4 count slope.

From: Trends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: results from The TREAT Asia HIV Observational Database

  Final model Initial treatment, before any class change or stop for more than 30 days Initial NNRTI-based regimen, before change or stop for more than 30 days Including patients with 4 or more CD4 slopes endpoints
  Difference* (95% CI) Difference* (95% CI) Difference* (95% CI) Difference* (95% CI)
   Observations = 10899   Observations = 6697   Observations = 4058   Observations = 9826
   Patients = 1676   Patients = 1353   Patients = 863   Patients = 1079
Current age, per 10 yrs older         
per unit -4.8 (-8.6, -1.0) -4.0 (-9.0, 1.0) -2.4 (-9.2, 4.4) -4.3 (-8.4, -0.2)
Concurrent viral load, per log10 copies per mL higher         
per unit -40.5 (-48.4, -32.6) -43.4 (-58.5, -28.4) -45.1 (-68.0, -22.2) -39.5 (-48.1, -30.9)
Concurrent CD4 per 100 per μL higher         
per unit 1.9 (0.2, 3.7) 3.4 (1.0, 5.7) 4.1 (0.9, 7.3) 1.9 (0.0, 3.8)
Disease stage         
CDC Category A* 0.0   0.0   0.0   0.0  
TB and/or other ADI 26.3 (15.6, 37.0) 29.9 (16.1, 43.7) 29.9 (13.9, 45.9) 26.4 (14.6, 38.1)
Non-TB ADI(s) 12.0 (2.5, 21.4) 16.4 (3.4, 29.4) 16.3 (-1.2, 33.9) 11.2 (0.9, 21.6)
Hepatitis B or C coinfection         
No* 0.0   0.0   0.0   0.0  
Yes -17.7 (-29.7, -5.7) -17.5 (-33.1, -2.0) -19.8 (-39.6, 0.0) -18.7 (-31.9, -5.5)
Time since ART initiation         
> 6 to ≤ 12 months* 0.0   0.0   0.0   0.0  
> 12 to ≤ 18 months -21.5 (-37.8, -5.2) -29.4 (-48.2, -10.6) -16.3 (-40.9, 8.3) -19.6 (-37.8, -1.4)
> 18 to ≤ 24 months -25.8 (-42.0, -9.7) -32.8 (-51.9, -13.7) -13.9 (-38.8, 10.9) -25.8 (-43.6, -7.9)
> 24 or more months -59.1 (-71.7, -46.5) -65.6 (-80.7, -50.5) -55.4 (-75.3, -35.5) -59.1 (-73.1, -45.0)
Constant 205.5 (174.4, 236.6) 207.2 (157.7, 256.6) 192.8 (121.4, 264.2) 200.6 (166.6, 234.6)
  1. * Difference were compared with the first category of each categorical variable