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Table 2 Random-effect linear regression analyses of trend of CD4 count (slope, cells/μL per year)

From: Trends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: results from The TREAT Asia HIV Observational Database

  Univariate Multivariate**
  Difference* (95% CI) p value Difference* (95% CI) p value
Sex       
Male* 0.0    0.0   
Female 9.5 (0.1, 18.9) 0.047 7.8 (-1.5, 17.2) 0.099
Current age       
per 10 years older -6.5 (-10.3, -2.7) 0.001 -4.8 (-8.6, -1.0) 0.013
Disease stage       
CDC Category A* 0.0    0.0   
TB with or without other ADI 24.4 (13.7, 35.1) < 0.001 26.3 (15.6, 37.0) < 0.001
Non-TB ADI(s) 3.7 (-5.6, 13.0) 0.433 12.0 (2.5, 21.4) 0.013
Haemglobin level       
per 1 g/dL higher 0.0 (-0.0, 0.1) 0.661 0.0 (-0.0, 0.1) 0.689
Concurrent CD4 count       
Per 100 cells/μL higher 1.3 (-0.3, 3.0) 0.116 1.9 (0.2, 3.7) 0.033
Concurrent viral load       
per log10 copies/mL higher -40.9 (-48.7, -33.2) < 0.001 -40.5 (-48.4, -32.6) < 0.001
Hepatitis B or C coinfection       
No* 0    0   
Yes -19.1 (-31.1, -7.0) 0.002 -17.7 (-29.7, -5.7) 0.004
Time since cART initiation       
> 6 to ≤ 12 months* 0.0    0.0   
> 12 to ≤ 18 months -21.3 (-37.7, -5.0) 0.011 -21.5 (-37.8, -5.2) 0.010
> 18 to ≤ 24 months -23.1 (-39.3, -7.0) 0.005 -25.8 (-42.0, -9.7) 0.002
> 24 or more months -58.0 (-70.3, -45.7) < 0.001 -59.1 (-71.7, -46.5) < 0.001
Initial cART containing NNRTI       
No* 0.0    0.0   
Yes 6.4 (-1.4, 14.1) 0.106 -1.3 (-9.2, 6.6) 0.749
Initial cART containing boosted PI       
No* 0.0    0.0   
Yes -0.8 (-10.5, 9.0) 0.880 -3.4 (-13.2, 6.3) 0.493
Initial cART containing abacavir       
No* 0.0      
Yes -12.9 (-25.8, 0.0) 0.050 -5.6 (-18.5, 7.3) 0.397
  1. * Difference were compared with the first category of each categorical variable.
  2. ** Constant term for multivariate model: 205.5 (174.4, 236.6) cells per μL per year.