- Research article
- Open Access
- Open Peer Review
This article has Open Peer Review reports available.
Common mental disorders in TB/HIV co-infected patients in Ethiopia
© Deribew et al; licensee BioMed Central Ltd. 2010
Received: 19 March 2010
Accepted: 9 July 2010
Published: 9 July 2010
The relationship between TB/HIV co-infection and common mental disorders (CMD) has been scarcely investigated. In this study, we compared the occurrence of CMD in TB/HIV co-infected and non-co-infected HIV patients in Ethiopia.
We conducted a cross sectional study in three hospitals in Ethiopia from February to April, 2009. The study population consisted of 155 TB/HIV co-infected and 465 non-co-infected HIV patients. CMD was assessed through face to face interviews by trained clinical nurses using the Kessler 10 scale. Several risk factors for CMD were assessed using a structured questionnaire.
TB/HIV co-infected patients had significantly (p = 0.001) greater risk of CMD (63.7%) than the non-co-infected patients (46.7%). When adjusted for the effect of potential confounding variables, the odds of having CMD for TB/HIV co-infected individuals was 1.7 times the odds for non-co-infected patients [OR = 1.7, (95%CI: 1.0, 2.9)]. Individuals who had no source of income [OR = 1.7, (95%CI: 1.1, 2.8)], and day labourers [OR = 2.4, 95%CI: 1.2, 5.1)] were more likely to have CMD as compared to individuals who had a source of income and government employees respectively. Patients who perceived stigma [OR = 2.2, 95%CI: 1.5, 3.2)] and who rate their general health as "poor" [OR = 10.0, 95%CI: 2.8, 35.1)] had significantly greater risk of CMD than individual who did not perceive stigma or who perceived their general health to be "good".
TB/HIV control programs should develop guidelines to screen and treat CMD among TB/HIV co-infected patients. Screening programs should focus on individuals with no source of income, jobless people and day labourers.
The global burden of disease report revealed that neuropsychiatric conditions accounted for up to a quarter of all the disability-adjusted life years lost. In low and middle income countries (LAMIC), neuropsychiatric disorders such as depression, anxiety and somatoform disorders account for 9.8% of the global burden of diseases.
The risk factors for mental health problems are complex . Poverty, low education, social exclusion, gender disadvantage, conflict and disasters are the major social determinants of mental disorders. Presence of medical illnesses  stigma and discrimination  also play a role in the development of depression.
The recent Lancet series on global mental health highlighted the lack of research on the interactions between mental disorders and communicable diseases such as tuberculosis (TB) and HIV/AIDS in low income settings . A high rate of depressive disorders has been reported among patients with HIV in high income countries. In the United States, a higher rate of depressive disorders was observed in HIV seropositive women (19%) than in HIV seronegative women (4.8%). Bing and colleagues  also reported that the 12-month prevalence of major depression was 36% in HIV infected adults compared to 7.6% in the general population in the United States. Some studies in LAMIC (Kenya, Democratic Republic of Congo and Thailand) also revealed that the rate of depression was higher in HIV seropositive patients than in HIV negative individuals .
The neurotropism of the HIV, opportunistic infections of the central nervous system and side effects of antiretroviral therapy (ART), especially the Efavirenz, may cause mental health problems. There is evidence that individuals with mental health problems are at higher risk of contracting HIV due to their higher risk behaviours.
Adherence to ART is adversely affected by depression[10–12]. Moreover, depression may reduce the CD4 lymphocyte count, increase viral load and mortality in patients with AIDS[13–15]. On the other hand, treatment of depression has been found to improve health outcomes in patients with HIV[14, 15].
Some studies have investigated the relationship between common mental disorders (CMD) and TB. A study conducted in Turkey showed that the prevalence of depression and anxiety was 19% for recently diagnosed patients with TB, 22% for defaulted TB patients, and 26% for patients with multidrug-resistant TB. The prevalence of CMD in 53 Nigerian TB patients recruited in a chest clinic was 30%, compared to 5% in healthy controls. A study done in Pakistan showed that the prevalence of depression and anxiety among TB patients was 43% and 47% respectively. TB patients have poor mental health and quality of life compared to the general population in United Kingdom.
TB/HIV co-infection poses immense diagnostic and economic challenges for developing countries. HIV is the strongest risk factor for the development of active pulmonary and extra pulmonary TB. TB also accelerates the deterioration of the immune status of patients with HIV [21–24] and it is one of the leading causes of mortality in people living with HIV/AIDS (PLHA). In Ethiopia, the rate of TB/HIV co-infection ranges from 45% in Addis Ababa to 52% in North Ethiopia.
Although several studies have been done concerning the interaction between either HIV/AIDS or TB with mental health problems, little is known about the effect of TB/HIV co-infection on common mental disorders. CMD, characterized by a significant level of depressive, anxiety and/or somatic symptoms are common among women in Ethiopia[28, 29]. So far the magnitude of CMD among men and the interaction between CMD and communicable diseases has not been investigated in Ethiopia. The objective of this study was to compare the occurrence of CMD in TB/HIV co-infected and non-co-infected HIV patients in Ethiopia.
Study Settings and Population
From February to March, 2009, we conducted a cross sectional study in three hospitals in Oromiya regional state of Ethiopia. Based on the availability of patients, we selected Adama, Nekemet and Jimma specialized hospitals in the east, west and southwest part of Ethiopia respectively. The methodology of this study is described elsewhere. In brief, the study population consisted of 155 TB/HIV co-infected and 465 non-co-infected HIV patients. All TB patients in the first two months of TB treatment were asked to participate in the study. For each TB/HIV co-infected patient, 3 non-co-infected HIV patients were also asked to participate. The latter were selected using a simple random sampling technique using the patients' unique identification number in the HIV clinics. TB was diagnosed using national TB guidelines. The non-co-infected patients were also screened for the presence of any signs and symptoms of TB. Non-co-infected HIV patients with a prior history of TB were excluded from the study. Patients who were less than 15 years old, had TB meningitis or another opportunistic infection, had a chronic illness like diabetes, cardiovascular disease or hypertension were excluded from the study.
Data collection procedures
CMD was assessed through face to face interviews by trained clinical nurses using the Kessler 10 scale which consisted of 10 five-point Likert scale (0 = never, 1 = rarely, 2 = some of the time, 3 = most of the time, 4 = all of the time) questions. For the diagnosis of CMD, the Kessler 10 scale was validated in Ethiopia against a gold standard of psychiatrists' diagnosis. In a previous study, two psychiatrists used the validated Comprehensive Psychopathology Rating Scale (CPRS) to diagnose CMD. The CPRS has 66 items; 40 symptoms based on the subjective report of the interviewee, 25 signs rated on the basis of observation during the interview and a global rating indicating presence of significant mental disorder. The presence of clearly defined symptoms or signs of mental disorder was rated on a 4-point scale (0-3). The definitions of each scale point were standardized as follows: 0 = not present; 1 = doubtful whether present, and not interfering with life; 2 = definitely present and of moderate severity; 3 = severe or incapacitating. The psychiatrists were asked to conduct a full psychiatric interview and then complete the CPRS ratings using all available information[28, 29]. Caseness of CMD was determined on the basis of any of the combination of depressive, anxiety and/or somatic symptoms present at clinically significant level. At the cut-off point of 6/7, the Kessler 10 scale had a sensitivity and specificity of 84.2% and 77.8% respectively to diagnose CMD.
Perceived stigma was measured using a questionnaire adopted from Berger et al. The instrument was highly reliable in a pre-test (Cronbach's α = 0.93). The stigma scale consisted of four-point Likert scale (strongly disagree, disagree, agree, strongly agree) questions concerning perceived isolation, shame, guilt and disclosure of the HIV status. Item scores of the stigma questions were summed to construct a single stigma variable. Participants were classified as having or not having perceived stigma using the mean of the stigma variable as cut-off point. Perceived general health of the participants (good, medium and poor) was assessed by asking the question 'How would you rate your health?'
Medical charts were reviewed to collect clinical information and level of adherence to antiretroviral and TB treatment. Individuals who took more than 95% of the prescribed doses were labelled as adherent to antiretroviral therapy.
Data were analyzed using SPSS version 16.0 software. Item scores of the Kessler scale were summed and individuals who scored above the cut-off point of 6/7 were labelled as having CMD. The Pearson's chi-square test was used to evaluate the association between exposure variables (TB/HIV co-infection, socio-demographic and clinical characteristics of the patients) and CMD. A stepwise logistic regression model was used to adjust for the effect of confounding variables. Variables significantly associated (P < 0.05) with CMD or TB/HIV co-infection in the Pearson's chi-square test were included in the logistic regression model.
Ethical clearance was obtained from the Jimma University ethical review board. Written informed consent was obtained from the study participants. To ensure confidentiality, we used codes to analyze the data.
All of the 465 non-co-infected HIV patients and 124 (80%) of the co-infected HIV patients participated in the study; 31 TB/HIV co-infected patients were lost to follow up before interview. Of the co-infected patients, smear negative, smear positive and extra pulmonary TB accounted for 61 (49.2%), 42 (33.9%), 21 (16.9%) respectively. From the total TB/HIV co-infected patients, 4 (3.2%) interrupted their TB treatment once.
Socio-demographic and clinical characteristics of the study population in three hospitals of, Ethiopia, April, 2009
TB/HIV coinfected patients
Age in Years
> = 35
Occupation (n = 580)
Have source of income
WHO staging(n = 582)
CD4 lymphocyte count(n = 489)
> = 200
The internal consistency of the Kessler 10 scale was high (Cronbach's α = 0.93) and correlation between items in the Kessler scale ranged from 0.50 to 0.79.
Association of socio-demographic and clinical characteristics and CMD in three hospitals of Ethiopia
Common Mental Disorders
> = 35
1.9(1.0, 3.7) *
2.2(1.0, 4.8) *
2.7(1.4, 5.0) *
2.4 (1.2, 5.1) *
3.6(1.8, 6.9) *
2.5 (1.1,5.6) *
Have source of income
1.7 (1.1,2.9) *
WHO staging(n = 582)
CD4 lymphocyte count(n = 489)
> = 200
Taking antiretroviral therapy
Adherence to antiretroviral therapy(ART)
ART regimen(n = 555)
Perceived General Health
4.7 (2.9,7.6) *
We assessed the occurrence of CMD in TB/HIV co-infected and non-co-infected patients using the Kessler scale (K10). Caseness of CMD was assessed using a cut-off point of 6/7 of the K10 which had a sensitivity and specificity of specificity of 84.2% and 77.8% against the psychiatrists' assessment using CPRS. Several studies showed that the K10 had strong psychometric properties[32, 34–36] and can discriminate between cases and non-cases reported in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)[32, 36]. In this study, 79 (64%) of the TB/HIV co-infected patients had CMD which is higher than the findings of Hanlon et al (33%)  and Tesfaye et al (40%) among women in Ethiopia. The prevalence of depression among HIV seropositive women (19%) in the United States was also lower as compared to our study. The differences in prevalence of mental disorders could be attributable to several factors including the population being studied, the study periods and the diagnostic tools. TB/HIV co-infected patients were 1.7 times more likely to have CMD than non-co-infected HIV patients. However, we did not find a significant association between CD4 lymphocyte count and CMD, which is consistent with several previous studies[37–39]. TB/HIV co-infected patients can be at higher risk of CMD as a result of stigma and discrimination by the society. We also found out that perceived stigma was one of the independent predictors of CMD. People with perceived stigma may have a low self image and be socially isolated which may predispose them to CMD.
Poverty is known to be a major risk factor for mental health problems . Many individuals in developing countries suffer from CMD as a result of stress caused by poverty[3, 41]. In this study, daily labourers and jobless individuals, both economically disadvantaged groups, were at a higher risk of CMD. Use of the locally made alcohol called "Katikala", which is common among daily labourers in Ethiopia , can also predispose to CMD. In contrast with other studies[3, 40, 43], we did not observe a significant association between marital status, gender and CMD.
In our study, the perception of poor general health was strongly associated with CMD. However, there could be a bi-directional relationship between perceived general health and depression. Poor perceived general health could have resulted from the presence of CMD.
Although antiretroviral drugs, particularly Efavirenz, can cause CMD, our result did not show an association between this drug and CMD. Adherence to antiretroviral therapy has been reported to be affected by depression. However, in our study we did not observe an association between adherence and CMD.
Some methodological limitations need to be noted in interpreting the findings of this study. First, the Kessler 10 scale is not 100% sensitive and specific and we might have misdiagnosed or missed some cases of CMD. Second, no detailed validation study was done for the stigma scale. Third, 20% of the TB/HIV co-infected patients were lost to follow-up which might introduce information bias. Important risk factors of CMD such as substance and alcohol use were not assessed.
TB/HIV co-infected patients were at higher risk of developing CMD than non-co-infected patients. Occupation, perceived stigma and perceived general health were other risk factors for CMD. TB/HIV control programs should develop guidelines to screen and treat CMD among TB/HIV co-infected patients. Screening programs should focus on individuals with no source of income, jobless people and day labourers. We recommend prospective cohort study to investigate the cause effect relationship of risk factors and CMD.
The authors acknowledge the HIV Prevention and Control Office (HAPCO) of the Oromiya regional state in Ethiopia for funding the study. The authors appreciate the study participants for their cooperation in providing the necessary information.
- Lopez AD, Mathers CD, Ezatti M, Jamison D, Murray C: Global burden of diseases and risk factors. 2006, New York, Oxford University PressView ArticleGoogle Scholar
- Patel V: Mental health in low- and middle-income countries. Br Med Bull. 2007, 81-82: 81-96. 10.1093/bmb/ldm010.View ArticlePubMedGoogle Scholar
- WHO: Mental Health, New understanding, new hope: The world health report, WHO, 2001. [http://www.who.int/whr/2001/en/]
- Prince M, Patel V, Saxena S, Maj M, Maselko J, Phillips MR, Rahman A: No health without mental health. Lancet. 2007, 370 (9590): 859-877. 10.1016/S0140-6736(07)61238-0.View ArticlePubMedGoogle Scholar
- Li L, Lee SJ, Thammawijaya P, Jiraphongsa C, Rotheram-Borus MJ: Stigma, social support, and depression among people living with HIV in Thailand. AIDS Care. 2009, 21 (8): 1007-1013. 10.1080/09540120802614358.View ArticlePubMedPubMed CentralGoogle Scholar
- Morrison MF, Petitto JM, Ten Have T, Gettes DR, Chiappini MS, Weber AL, Brinker-Spence P, Bauer RM, Douglas SD, Evans DL: Depressive and anxiety disorders in women with HIV infection. Am J Psychiatry. 2002, 159 (5): 789-796. 10.1176/appi.ajp.159.5.789.View ArticlePubMedGoogle Scholar
- Bing EG, Burnam MA, Longshore D, Fleishman JA, Sherbourne CD, London AS, Turner BJ, Eggan F, Beckman R, Vitiello B, et al: Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Arch Gen Psychiatry. 2001, 58 (8): 721-728. 10.1001/archpsyc.58.8.721.View ArticlePubMedGoogle Scholar
- Maj M, Janssen R, Starace F, Zaudig M, Satz P, Sughondhabirom B, Luabeya MA, Riedel R, Ndetei D, Calil HM, et al: WHO Neuropsychiatric AIDS study, cross-sectional phase I. Study design and psychiatric findings. Arch Gen Psychiatry. 1994, 51 (1): 39-49.View ArticlePubMedGoogle Scholar
- Koblin BA, Husnik MJ, Colfax G, Huang Y, Madison M, Mayer K, Barresi PJ, Coates TJ, Chesney MA, Buchbinder S: Risk factors for HIV infection among men who have sex with men. Aids. 2006, 20 (5): 731-739. 10.1097/01.aids.0000216374.61442.55.View ArticlePubMedGoogle Scholar
- Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, Wagener MM, Singh N: Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000, 133 (1): 21-30.View ArticlePubMedGoogle Scholar
- Ammassari A, Antinori A, Aloisi MS, Trotta MP, Murri R, Bartoli L, Monforte AD, Wu AW, Starace F: Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons. Psychosomatics. 2004, 45 (5): 394-402. 10.1176/appi.psy.45.5.394.View ArticlePubMedGoogle Scholar
- Gordillo V, del Amo J, Soriano V, Gonzalez-Lahoz J: Sociodemographic and psychological variables influencing adherence to antiretroviral therapy. Aids. 1999, 13 (13): 1763-1769. 10.1097/00002030-199909100-00021.View ArticlePubMedGoogle Scholar
- Leserman J: Role of depression, stress, and trauma in HIV disease progression. Psychosom Med. 2008, 70 (5): 539-545. 10.1097/PSY.0b013e3181777a5f.View ArticlePubMedGoogle Scholar
- Ironson G, O'Cleirigh C, Fletcher MA, Laurenceau JP, Balbin E, Klimas N, Schneiderman N, Solomon G: Psychosocial factors predict CD4 and viral load change in men and women with human immunodeficiency virus in the era of highly active antiretroviral treatment. Psychosom Med. 2005, 67 (6): 1013-1021. 10.1097/01.psy.0000188569.58998.c8.View ArticlePubMedPubMed CentralGoogle Scholar
- Ickovics JR, Hamburger ME, Vlahov D, Schoenbaum EE, Schuman P, Boland RJ, Moore J: Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study. Jama. 2001, 285 (11): 1466-1474. 10.1001/jama.285.11.1466.View ArticlePubMedGoogle Scholar
- Aydin IO, Ulusahin A: Depression, anxiety comorbidity, and disability in tuberculosis and chronic obstructive pulmonary disease patients: applicability of GHQ-12. Gen Hosp Psychiatry. 2001, 23 (2): 77-83. 10.1016/S0163-8343(01)00116-5.View ArticlePubMedGoogle Scholar
- Aghanwa HS, Erhabor GE: Demographic/socioeconomic factors in mental disorders associated with tuberculosis in southwest Nigeria. J Psychosom Res. 1998, 45 (4): 353-360. 10.1016/S0022-3999(98)00006-3.View ArticlePubMedGoogle Scholar
- Husain MO, Dearman SP, Chaudhry IB, Rizvi N, Waheed W: The relationship between anxiety, depression and illness perception in tberculosis patients in Pakistan. Clin Pract Epidemiol Ment Health. 2008, 4: 4-10.1186/1745-0179-4-4.View ArticlePubMedPubMed CentralGoogle Scholar
- Kruijshaar ME, Lipman M, Essink-Bot ML, Lozewicz S, Creer D, Dart S, Maguire H, Abubakar I: Health status of UK patients with active tuberculosis. Int J Tuberc Lung Dis. 14 (3): 296-302.Google Scholar
- WHO: Global Tuberculosis control: Surveillance, planning and Financing. World Report 2008. [http://www.who.int/tb/publications/global_report/en/]
- Aliyu MH, Salihu HM: Tuberculosis and HIV disease: two decades of a dual epidemic. Wien Klin Wochenschr. 2003, 115 (19-20): 685-697. 10.1007/BF03040884.View ArticlePubMedGoogle Scholar
- Maher D, Watt CJ, Williams BG, Raviglione M, Dye C: Tuberculosis deaths in countries with high HIV prevalence: what is their use as an indicator in tuberculosis programme monitoring and epidemiological surveillance?. Int J Tuberc Lung Dis. 2005, 9 (2): 123-127.PubMedGoogle Scholar
- Harries AD, Hargreaves NJ, Kemp J, Jindani A, Enarson DA, Maher D, Salaniponi FM: Deaths from tuberculosis in sub-Saharan African countries with a high prevalence of HIV-1. Lancet. 2001, 357 (9267): 1519-1523. 10.1016/S0140-6736(00)04639-0.View ArticlePubMedGoogle Scholar
- Mukadi YD, Maher D, Harries A: Tuberculosis case fatality rates in high HIV prevalence populations in sub-Saharan Africa. Aids. 2001, 15 (2): 143-152. 10.1097/00002030-200101260-00002.View ArticlePubMedGoogle Scholar
- WHO: Stop TB Department and Department of HIV/AIDS. Interim policy on collaborative TB/HIV activities. WHO/HTM/TB/2004.330. 2004Google Scholar
- Demissie MLB, Tegbaru B: Human Immunodeficiency virus (HIV) infection in tuberculosis patients in Addis Ababa. Ethiop. 2000, 277-282. 14Google Scholar
- Kassu A, Mengistu G, Ayele B, Diro E, Mekonnen F, Ketema D, Moges F, Mesfin T, Getachew A, Ergicho B, et al: Coinfection and clinical manifestations of tuberculosis in human immunodeficiency virus-infected and -uninfected adults at a teaching hospital, northwest Ethiopia. J Microbiol Immunol Infect. 2007, 40 (2): 116-122.PubMedGoogle Scholar
- Tesfaye M, Hanlon C, Wondimagegn D, Alem A: Detecting postnatal common mental disorders in Addis Ababa, Ethiopia: validation of the Edinburgh Postnatal Depression Scale and Kessler Scales. J Affect Disord. 122 (1-2): 102-108. 10.1016/j.jad.2009.06.020.Google Scholar
- Hanlon C, Medhin G, Alem A, Araya M, Abdulahi A, Hughes M, Tesfaye M, Wondimagegn D, Patel V, Prince M: Detecting perinatal common mental disorders in Ethiopia: validation of the self-reporting questionnaire and Edinburgh Postnatal Depression Scale. J Affect Disord. 2008, 108 (3): 251-262. 10.1016/j.jad.2007.10.023.View ArticlePubMedGoogle Scholar
- Deribew A, Tesfaye M, Hailmichael Y, Negussu N, Daba S, Wogi A, Belachew T, Apers L, Colebunders R: Tuberculosis and HIV co-infection: its impact on quality of life. Health Qual Life Outcomes. 2009, 7: 105-10.1186/1477-7525-7-105.View ArticlePubMedPubMed CentralGoogle Scholar
- Ministry of Health, Ethiopia: TB, leprosy and TB/HIV prevention and control program, Manual. Addis Ababa, Ethiopia. 2008, [http://www.moh.gov.et/]Google Scholar
- Kessler RC, Andrews G, Colpe LJ, Hiripi E, Mroczek DK, Normand SL, Walters EE, Zaslavsky AM: Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med. 2002, 32 (6): 959-976. 10.1017/S0033291702006074.View ArticlePubMedGoogle Scholar
- Berger BE, Ferrans CE, Lashley FR: Measuring stigma in people with HIV: psychometric assessment of the HIV stigma scale. Res Nurs Health. 2001, 24 (6): 518-529. 10.1002/nur.10011.View ArticlePubMedGoogle Scholar
- Donker T, Comijs H, Cuijpers P, Terluin B, Nolen W, Zitman F, Penninx B: The validity of the Dutch K10 and extended K10 screening scales for depressive and anxiety disorders. Psychiatry Res. 176 (1): 45-50. 10.1016/j.psychres.2009.01.012.Google Scholar
- Fassaert T, De Wit MA, Tuinebreijer WC, Wouters H, Verhoeff AP, Beekman AT, Dekker J: Psychometric properties of an interviewer-administered version of the Kessler Psychological Distress scale (K10) among Dutch, Moroccan and Turkish respondents. Int J Methods Psychiatr Res. 2009, 18 (3): 159-168. 10.1002/mpr.288.View ArticlePubMedGoogle Scholar
- Furukawa TA, Kessler RC, Slade T, Andrews G: The performance of the K6 and K10 screening scales for psychological distress in the Australian National Survey of Mental Health and Well-Being. Psychol Med. 2003, 33 (2): 357-362. 10.1017/S0033291702006700.View ArticlePubMedGoogle Scholar
- Evans DL, Ten Have TR, Douglas SD, Gettes DR, Morrison M, Chiappini MS, Brinker-Spence P, Job C, Mercer DE, Wang YL, et al: Association of depression with viral load, CD8 T lymphocytes, and natural killer cells in women with HIV infection. Am J Psychiatry. 2002, 159 (10): 1752-1759. 10.1176/appi.ajp.159.10.1752.View ArticlePubMedGoogle Scholar
- Perry S, Fishman B, Jacobsberg L, Frances A: Relationships over 1 year between lymphocyte subsets and psychosocial variables among adults with infection by human immunodeficiency virus. Arch Gen Psychiatry. 1992, 49 (5): 396-401.View ArticlePubMedGoogle Scholar
- Rabkin JG, Williams JB, Remien RH, Goetz R, Kertzner R, Gorman JM: Depression, distress, lymphocyte subsets, and human immunodeficiency virus symptoms on two occasions in HIV-positive homosexual men. Arch Gen Psychiatry. 1991, 48 (2): 111-119.View ArticlePubMedGoogle Scholar
- Perlick DA, Rosenheck RA, Clarkin JF, Sirey JA, Salahi J, Struening EL, Link BG: Stigma as a barrier to recovery: Adverse effects of perceived stigma on social adaptation of persons diagnosed with bipolar affective disorder. Psychiatr Serv. 2001, 52 (12): 1627-1632. 10.1176/appi.ps.52.12.1627.View ArticlePubMedGoogle Scholar
- Araya R, Rojas G, Fritsch R, Acuna J, Lewis G: Common mental disorders in Santiago, Chile: prevalence and socio-demographic correlates. Br J Psychiatry. 2001, 178: 228-233. 10.1192/bjp.178.3.228.View ArticlePubMedGoogle Scholar
- Deribew A: Distribution of Most-at-risk Population Groups and their perceptions towards HIV/AIDS: A Baseline Survey in Amhara Region for the Implementation of Mobile HIV Counselling and Testing. 2009, Bethesda, MD: Private Sector Program-Ethiopia, Abt Associates IncGoogle Scholar
- Seedat S, Scott KM, Angermeyer MC, Berglund P, Bromet EJ, Brugha TS, Demyttenaere K, de Girolamo G, Haro JM, Jin R, et al: Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys. Arch Gen Psychiatry. 2009, 66 (7): 785-795. 10.1001/archgenpsychiatry.2009.36.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/10/201/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.