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Table 4 Association studies of the TNF genes with tuberculosis.

From: Genetic polymorphisms in TNFgenes and tuberculosis in North Indians

S. No Reference Polymorphisms Investigated Location Population Sample size Results
1. Selvaraj et al. [20] TNFA -238, -308 and LTA (Nco I) Promoter; Intron 1 South Indian 210 PTB patients and 120 normal controls (NC) No association with pulmonary TB (PTB).
2. Ates et al. [17] TNFA -308 G/A, -238 G/A, -376 G/A Promoter Turkish 128 TB patients and 80 NC No association with TB.
3. Vejbaesya et al. [21] TNFA +488, -238, and -308 Promoter Thai 149 TB patients and 147 NC No association with TB.
4. Amirzargar et al. [37] TNFA -308, G/A -238 Promoter Iranian 41 PTB and 123 NC -238 polymorphism was associated with pulmonary TB (p = 0.0009).
5. Shaw et al. [42] Linkage study Markers across the genome Northern Brazilian 98 pedigrees, with 704 individuals Minor role of TNFA in control of TB.
6. Correa et al. [35, 36] TNFA -308, G/A -238 Promoter Columbia 138 TB and 419 NC Association of TNF1 with TB (OR: 1.9, 95%C.I. 1.2-3.1, p = 0.02)
7. Wu et al. [24] TNFA -308 Promoter Chinese 61 PTB patients and 122 PTB-free miners. Lack of association with TB.
8. Larcombe et al. [26] TNFA -308 Promoter Canadian Aboriginal Three cohorts n = 61, 42 and 91 for Dené, Cree and healthy Caucasians, respectively Lack of association with TB.
9. Henao et al. [25] TNFA -308 Promoter Colombian 54 tuberculin-negative NC, 81 tuberculin-positive NC, 140 PTB patients, 30 with pleural TB and 20 with miliary TB Lack of association with TB.
10. Kumar et al. [34] TNFA -308 Promoter Indian 145 TB and 211 NC Lack of association with TB.
11. Oh et al. [18] TNFA -308 Promoter Korean 117 NC, 80 newly diagnosed TB patients and 65 patients with recurrent TB TNFA gene does not affect differential TB susceptibility.
12. Sharma et al. [Current] LTA_NcoI; TNFA -238, -308, -857, -863, -1031 Intron 1; Promoter North Indian 185 TB patients and 155 NC Lack of association with TB.
  1. PTB = pulmonary tuberculosis; NC = normal controls